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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 836 - 841 (6page)
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초록· 키워드
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In the era of personal genomics, predicting the individual response to drug-treatment is a challenge of biomedical research.
The aim of this study was to validate whether interaction information between genetic and transcriptional signatures are promising features to predict a drug response.
Because drug resistance/susceptibilities result from the complex associations of genetic and transcriptional activities, we predicted the inter-relationships between genetic and transcriptional signatures. With this concept, captured genetic polymorphisms and transcriptional profiles were prepared in cancer samples. By splitting ninety-nine samples into a trial set (n = 30) and a test set (n = 69), the outperformance of relationship-focused model (0.84 of area under the curve in trial set, P = 2.90 × 10-4) was presented in the trial set and validated in the test set, respectively. The prediction results of modeling show that considering the relationships between genetic and transcriptional features is an effective approach to determine outcome predictions of drug-treatment.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Denkert, C. / 2009 / A prognostic gene expression index in ovarian cancer - validation across different independent data sets / J. Pathol. 218 : 273 ~ 280
Fuchs, D. / 2010 / Salinomycin overcomes ABC transportermediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells / Biochem. Biophys. Res. Comm
Gang Bai / 2010 / Promoter demethylation mediates the expression of ZNF645, a novel cancer/testis gene / BMB reports 43 (6) : 400 ~ 406
Green, H. / 2006 / mdr-1 single nucleotide polymorphisms in ovarian cancer tissue: G2677T/A correlates with response to paclitaxel chemotherapy / Clin. Cancer Res. 12 : 854
Hartmann, L. C. / 2005 / Gene expression profiles predict early relapse in ovarian cancer after platinum-paclitaxel chemotherapy / Clin. Cancer Res. 11 : 2149 ~ 2155
Fuchs, D. / 2010 / Salinomycin overcomes ABC transportermediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells / Biochem. Biophys. Res. Comm
Gang Bai / 2010 / Promoter demethylation mediates the expression of ZNF645, a novel cancer/testis gene / BMB reports 43 (6) : 400 ~ 406
Green, H. / 2006 / mdr-1 single nucleotide polymorphisms in ovarian cancer tissue: G2677T/A correlates with response to paclitaxel chemotherapy / Clin. Cancer Res. 12 : 854
Hartmann, L. C. / 2005 / Gene expression profiles predict early relapse in ovarian cancer after platinum-paclitaxel chemotherapy / Clin. Cancer Res. 11 : 2149 ~ 2155
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