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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국인체미용예술학회 한국인체미용예술학회지 한국인체미용예술학회지 제17권 제2호
발행연도
2016.1
수록면
45 - 55 (11page)

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초록· 키워드

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Acetone is one of the organic solvents that causes skin barrier disruption such as eczema and dermatitis, ichthyosis and xerosis, and ROS (reactive oxygen species) paly a role of skin toxicity. This study is focused on investigating the effect of ROS of applied acetone. Acetone was applied to mice skin (0.25ml/㎠) four times (6h, 12h, 18h, 24h) every day for two or four days. Increased activity of acid phosphatase (ACP) and increased content of lipid peroxide (LPO) in acetone was determined in the applied group for four days(4ACE) compared with the acetone applied group for two days (2ACE). As for the ROS generating enzymes, one of them, xanthine oxidase (XO) showed no differences between control and 2ACE despite the significantly different 4ACE. There were some differences between 2ACE and 4ACE on the activities of cytochrome P450 dependent aniline hydroxylase (CYPdAH), which seemed to be the increased rates of acetone metabolites. There were more decreased rates of the activities of ROS scavenging enzymes, glutathione peroxidase (GPx), catalase (CAT), superoxide dismutae (SOD), glutathione S-transferase (GST), and glutathione (GSH) contents in 4ACE compared with 2ACE. The results indicate that the damaged skin tissue could cause unbalance of the ROS generating system and scavenging system by the frequent exposure of acetone application.

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