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Predictive factors for early response to methimazole in children and adolescents with Graves disease: a single-institute study between 1993 and 2013
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논문 기본 정보

Type
Academic journal
Author
Journal
대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제21권 제2호 KCI Accredited Journals
Published
2016.1
Pages
70 - 74 (5page)

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Predictive factors for early response to methimazole in children and adolescents with Graves disease: a single-institute study between 1993 and 2013
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Purpose: We aimed to investigate the predictive factors for early response to methimazole (MMI) in pediatric patients with Graves disease (GD). Methods: Our study included 44 pediatric patients who were diagnosed with GD between January 1, 1993, and December 31, 2013, and were available for followup, achieving a normalization of thyroid functions (TFs) at the Chonbuk National University Hospital Pediatric Department. We retrospectively analyzed TFs such as tri-iodothyronine (T3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), and thyroid antibody levels at diagnosis. We also examined their family history of thyroid disease, symptoms at presentation, and normalization time for TF after treatment. We divided our clinical series of patients into the following 4 age groups: <7 years old, 7–12 years old, 13–15 years old, and 16–18 years old. Results: At diagnosis, the time of normalization of T3 was significantly shorter in the higher antimicrosomal antibody (AMA) group compared with the lower AMA group (2.53 months vs. 6.18 months) (P<0.05). However, the time of normalization of T3/fT4/TSH had no significant correlations with other variables such as age, sex, a family history of thyroid diseases, thyroglobulin, thyroid-stimulating immunoglobulin, or antithyroglobulin antibody (ATA). Conclusion: Higher serological titers of AMA at diagnosis may have prognostic value in the response to initial MMI treatment in pediatric hyperthyroid GD patients.
#Graves disease #Triiodothyronine #Adolescent #Methimazole #thyroid microsomal antibodies

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References (26)

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Bettendorf M / 2002 / Thyroid disorders in children from birth to adolescence / Eur J Nucl Med Mol Imaging 29(Suppl 2):S439~S446 google schola Sperling MA / 2002 / Pediatric endocrinology / WB Saunders Co :187~209 google schola Jaruratanasirikul S / 2006 / Thyrotoxicosis in children: treatment and outcome / J Med Assoc Thai 89:967~973 google schola Abraham-Nordling M / 2011 / Incidence of hyperthyroidism in Sweden / Eur J Endocrinol 165:899~905 google schola Metso S / 2008 / Graves' disease / N Engl J Med 359:1408~1409 google schola

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