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자료유형
학술저널
저자정보
저널정보
대한한방소아과학회 대한한방소아과학회지 대한한방소아과학회지 제19권 제1호
발행연도
2005.1
수록면
35 - 52 (18page)

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Objective : The purpose of this study is to examine effect that KDKEJ used to atopic dermatitis disease patient get in atopy eruption control experimentally. Methods : We analyzed the expression of IgE, IL-6, IL-4, IL-5 and IL-13's level in serum, and IFN-γ' production by KDKEJ extract. We also analyzed KDKEJ extract get to NC/Nga mice's skin establishment analyzes neck-back skin after biopsy, and H&E method measured about epidermis and dermis part in comparison with control group. Results : In this research KDKEJ extract as treatment result to a NC/Nga mice, IgE and IL-6 content in serum decreased remarkably than control group. And decreased than result control group which measure IL-4, IL-5, IL-13's level in serum, and IFN-γ' production secreted in Th1 cell displayed increase by KDKEJ extract. IL-4 and IFN-γ's gene revelation amount displayed marked decrease than control group in result that observe effect that get in skin of a NC/Nga mice. Also, in culture supernatant which cultivate for 14 day after separate skin cell, IL-13 and IL-6 production decreased than control group. KDKEJ extract get to NC/Nga mice's skin establishment analyzes neck-back skin after biopsy, and dye by H&E method decreased about epidermis and inflammation of dermis part remarkably than control group. Conclusions : These results suggest that Th1 cell and Th2 cell observe to be shifted by secretion amount of IL-4 and IFN-γ by KDKEJ extract could know that KDKEJ extract can use usefully in allergy autoimmune disease.

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