지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Cerebrovascular complications after orthotopic heart transplantation (OHT) are more common in comparison with neurological sequelae subsequent to routine cardiac surgery. Ischemic stroke and transient ischemic attack (TIA) are more common (with an incidence of up to 13%) than intracranial hemorrhage (2.5%). Clinically, ischemic stroke is manifested by the appearance of focal neurologic deficits, although sometimes a stroke may be silent or manifests itself by the appearance of encephalopathy, reflecting a diffuse brain disorder. Ischemic stroke subtypes distribution in perioperative and postoperative period after OHT is very different from classical distribution, with different pathogenic mechanisms. Infact, ischemic stroke may be caused by less common and unusual mechanisms, linked to surgical procedures and to postoperative inflammation, peculiar to this group of patients. However, many strokes (40%) occur without a well-defined etiology (cryptogenic strokes). A silent atrial fibrillation (AF) may play a role in pathogenesis of these strokes and P wave dispersion may represent a predictor of AF. In OHT patients, P wave dispersion correlates with homocysteine plasma levels and hyperhomocysteinemia could play a role in the pathogenesis of these strokes with multiple mechanisms increasing the risk of AF. In conclusion, stroke after heart transplantation represents a complication with considerable impact not only on mortality but also on subsequent poor functional outcome.
목차
등록된 정보가 없습니다.
참고문헌 (81)
참고문헌 신청
Amarenco P / 2009 / Classification of stroke subtypes / Cerebrovasc Dis 27:493~501
Towfighi A / 2011 / Stroke declines from third to fourth leading cause of death in the United States : historical perspective and challenges ahead / Stroke 42:2351~2355
Alejaldre A / 2010 / Cerebrovascular complications after heart transplantation / Curr Cardiol Rev 6:214~217
Deng MC / 2002 / Cardiac transplantation / Heart 87:177~184
Toyoda Y / 2013 / Present status and future perspectives of heart transplantation / Circ J 77:1097~1110
Towfighi A / 2011 / Stroke declines from third to fourth leading cause of death in the United States : historical perspective and challenges ahead / Stroke 42:2351~2355
Alejaldre A / 2010 / Cerebrovascular complications after heart transplantation / Curr Cardiol Rev 6:214~217
Deng MC / 2002 / Cardiac transplantation / Heart 87:177~184
Toyoda Y / 2013 / Present status and future perspectives of heart transplantation / Circ J 77:1097~1110
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