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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 159 - 171 (13page)
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초록· 키워드
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Objectives
This study was evaluated the effects of CSE the regulatory mechanism of NO and cytokines in the LPS-stimulated Raw 264.7 cells.
Methods
The Coicis Semen MeOH extract dissolved in EMEM for 1 hour prior to the addition of LPS(1μg/ml). The cell viability was measured by MTT assay, and Nitric Oxide production was monitored by measuring the nitrite content in culture medium. The levels of cytokine and PGE2 were analyzed by sandwich immunoassays.
Results
CSE inhibited the production of NO (0.03 and 0.1 mg/ml), TNF-α (0.03 and 0.1 mg/ml), IL-1β (0.03 and 0.1 mg/ml), IL-6 (0.03, 0.1 mg/ml) and PGE2(0.03 and 0.1 mg/ml) in Raw 264.7 cells activated with LPS(lipopolysaccharide).
Conclusion
According to the results above, Coicis Semen can produce anti-inflammatory effect, which may play a role in adjunctive therapy in Gram-negative bacterial infections.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Cetkovic-Cvrlje M / 1994 / TNF and IFNγ potentiate the deleterious effects of IL-1β on mouse pancreatic islets mainly via generation of nitric oxid / Cytokine 6 : 399 ~ 40
Chiou WF / 2001 / Camptothecin suppresses nitric oxide biosynthesis in RAW 264.7 macrophages / Life Sci 69 : 625 ~ 635
Corbett JA / 1995 / Intraislet release of interleukin-1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide syntheses / J Exp Med 181 : 55
Higuchi M / 1990 / Cytolytic mechanism of activated macrophages. Tumor necrosis factor and L-arginine-dependent mechanism acts as synergistically as the major cytolytic mecha
Jin-Ho Lim / 2007 / Inhibitory effect of Yongdamsagantang water extract on IL-6 and nitric oxide production in lipopolysaccharide-activated RAW 264.7 cells / Oriental Pharma
Chiou WF / 2001 / Camptothecin suppresses nitric oxide biosynthesis in RAW 264.7 macrophages / Life Sci 69 : 625 ~ 635
Corbett JA / 1995 / Intraislet release of interleukin-1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide syntheses / J Exp Med 181 : 55
Higuchi M / 1990 / Cytolytic mechanism of activated macrophages. Tumor necrosis factor and L-arginine-dependent mechanism acts as synergistically as the major cytolytic mecha
Jin-Ho Lim / 2007 / Inhibitory effect of Yongdamsagantang water extract on IL-6 and nitric oxide production in lipopolysaccharide-activated RAW 264.7 cells / Oriental Pharma
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