지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
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Background and Purpose Leptomeningeal collaterals maintain arterial perfusion in acute arterialocclusion but may fluctuate subject to arterial blood pressure (ABP). We aim to investigate therelationship between ABP and collaterals as assessed by computer tomography (CT) perfusion inacute ischemic stroke.
Methods We retrospectively analyzed acute anterior circulation ischemic stroke patients with CTperfusion from 2009 to 2014. Collateral status using relative filling time delay (rFTD) determined bytime delay of collateral-derived contrast opacification within the Sylvian fissure, from 0 seconds tounlimited count. The data were analyzed by zero-inflated negative binomial regression modelincluding an appropriate interaction examining in the model in terms of occlusion location andonset-to-CT time (OCT).
Results Two hundred and seventy patients were included. We found that increment of 10 mm Hgin BP, the odds that a patient would have rFTD equal to 0 seconds increased by 27.9% in systolicBP (SBP) (P=0.001), by 73.9% in diastolic BP (DBP) (P<0.001) and by 68.5% in mean BP (MBP)(P<0.001). For patients with rFTD not necessarily equal to 0 seconds, every 10 mm Hg increase inBP, there was a 7% decrease in expected count of seconds for rFTD in SBP (P=0.002), 10% decreasefor rFTD in DBP and 11% decrease for rFTD in MBP. The arterial occlusion location and OCT showedno significant interaction in the BP-rFTD relationship (P>0.05).
Conclusions In acute ischemic stroke, higher ABP is possibly associated with improvedleptomeningeal collaterals as identified by decreased rFTD.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
He J / 2014 / Effects of immediate blood pressure reduction on death and major disability in patients with acute ischemic stroke: the CATIS randomized clinical trial / JAMA 311:479~489
Souza LC / 2012 / Malignant CTA collateral profile is highly specific for large admission DWI infarct core and poor outcome in acute stroke / AJNR Am J Neuroradiol 33:1331~1336
McVerry F / 2012 / Systematic review of methods for assessing leptomeningeal collateral flow / AJNR Am J Neuroradiol 33:576~582
Wu B / 2008 / Collateral circulation imaging: MR perfusion territory arterial spin-labeling at 3T / AJNR Am J Neuroradiol 29:1855~1860
Chng SM / 2008 / Territorial arterial spin labeling in the assessment of collateral circulation: comparison with digital subtraction angiography / Stroke 39:3248~3254
Souza LC / 2012 / Malignant CTA collateral profile is highly specific for large admission DWI infarct core and poor outcome in acute stroke / AJNR Am J Neuroradiol 33:1331~1336
McVerry F / 2012 / Systematic review of methods for assessing leptomeningeal collateral flow / AJNR Am J Neuroradiol 33:576~582
Wu B / 2008 / Collateral circulation imaging: MR perfusion territory arterial spin-labeling at 3T / AJNR Am J Neuroradiol 29:1855~1860
Chng SM / 2008 / Territorial arterial spin labeling in the assessment of collateral circulation: comparison with digital subtraction angiography / Stroke 39:3248~3254
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