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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background and Purpose The primary mechanism underlying paramedian pontine infarction (PPI) is atheroma obliterating the perforators. Here, we encountered a patient with PPI in the post-stenotic area of basilar artery (BA) without a plaque, shown by high-resolution magnetic resonance imaging (HR-MRI). We performed an experiment using a 3D-printed BA model and a particle image velocimetry (PIV) to explore the hemodynamic property of the post-stenotic area and the mechanism of PPI.
Methods 3D-model of a BA stenosis was reconstructed with silicone compound using a 3D-printer based on the source image of HR-MRI. Working fluid seeded with fluorescence particles was used and the velocity of those particles was measured horizontally and vertically. Furthermore, microtubules were inserted into the posterior aspect of the model to measure the flow rates of perforators (pre-and post-stenotic areas). The flow rates were compared between the microtubules.
Results A recirculating flow was observed from the post-stenotic area in both directions forming a spiral shape. The velocity of the flow in these regions of recirculation was about one-tenth that of the flow in other regions. The location of recirculating flow well corresponded with the area with low-signal intensity at the time-of-flight magnetic resonance angiography and the location of PPI. Finally, the flow rate through the microtubule inserted into the post-stenotic area was significantly decreased comparing to others (P<0.001).
Conclusions Perforator infarction may be caused by a hemodynamic mechanism altered by stenosis that induces a recirculation flow. 3D-printed modeling and PIV are helpful understanding the hemodynamics of intracranial stenosis.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Bassetti C / 1996 / Isolated infarcts of the pons / Neurology 46:165~175
Klein IF / 2005 / High-resolution MRI identifies basilar artery plaques in paramedian pontine infarct / Neurology 64:551~552
Mehdiratta M / 2007 / Basilar artery branch disease imaged by magnetic resonance imaging / Arch Neurol 64:1666
Kim BJ / 2014 / Perforator infarction immediately distal to the stenosis of parental artery: is it hemodynamic? / J Stroke Cerebrovasc Dis 23:1991~1993
Choi JY / 2002 / Analysis of errors in medical rapid prototyping models / Int J Oral Maxillofac Surg 31:23~32
Klein IF / 2005 / High-resolution MRI identifies basilar artery plaques in paramedian pontine infarct / Neurology 64:551~552
Mehdiratta M / 2007 / Basilar artery branch disease imaged by magnetic resonance imaging / Arch Neurol 64:1666
Kim BJ / 2014 / Perforator infarction immediately distal to the stenosis of parental artery: is it hemodynamic? / J Stroke Cerebrovasc Dis 23:1991~1993
Choi JY / 2002 / Analysis of errors in medical rapid prototyping models / Int J Oral Maxillofac Surg 31:23~32
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