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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한뇌졸중학회 대한뇌졸중학회지 대한뇌졸중학회지 제3권 제2호
발행연도
2001.1
수록면
147 - 152 (6page)

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Background & Objectives : Life-long therapy with oral anticoagulant(OAC) is recommended in patients with prosthetic mechanical heart valves(PHV). It is uncertain when to safely restart anticoagulation in those who developed OAC-related intracranial hemorrhage(ICH). We undertook this study to investigate the incidence and causative factors of enlargement of ICH after early restarting OAC, and to evaluate the long-term prognosis. Methods: Twenty-two patients with PHV were admitted due to ICH during OAC from May 1994 to April 2001. We selected 15 patients who withdrew and restarted OAC within 14 days after diagnosis of ICH and underwent at least 2 brain CT scans. The volume of ICH was measured on the axial images of the initial and follow-up CT scans. Results: All had SDH and maximum thickness of the SDH ranged from 0.5 to 2(mean 1) cm. OAC was discontinued for 6 ±4.1 days and 5 patients received IV heparin during their withdrawal periods. SDH was evacuated in 10 patients with large SDH(maximum thickness ≥1 cm). The enlargement of SDH with OAC was detected in 3 patients(20%) and no thromboembolic complication was observed. The patients with enlargement of hematoma showed higher initial diameter of hematoma(P <.05) and had less frequent incidence of infusion of coagulation factor within 1 day(P <.05) than those without enlargement. During a mean follow-up of 30 months, two(13.3%) patients had recurrent intracranial bleeding and no one had embolic event or cerebral infarct on OAC. Conclusions: Our favorable final outcomes suggest that OAC could be started relatively safely in the patients with PHV and OAC-related SDH within 14 days after the diagnosis. Korean Journal of Stroke 2001;3(2): 147~152

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