지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제22권 제3호
- 발행연도
- 2017.1
- 수록면
- 176 - 182 (7page)
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초록· 키워드
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Purpose: Precocious puberty has significantly increased recently. While obesity is associated with puberty timing, the relationship between obesity and central precocious puberty (CPP) remains controversial. The purpose of this study was to determine whether insulin resistance is associated with bone age (BA) advancement in girls with CPP. Methods: We retrospectively analyzed the records of 804 girls referred for puberty evaluation. Anthropometric measurements, BA, sex hormone, sex hormone binding globulin (SHBG), and insulin levels, lipid profiles, and gonadotropin releasing hormone stimulation tests were assessed. Insulin resistance parameters were calculated using the homeostasis model assessment-insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) models. Results: BA, BA advancement, free estradiol index, insulin, and HOMA-IR increased significantly in girls with high body mass index (BMI) compared with that of girls with low BMI in cases of CPP. HOMA-IR was positively correlated with BA advancement and BMI but negatively correlated with SHBG. QUICKI was negatively correlated with BA advancement and BMI and positively correlated with SHBG. When HOMA-IR increased by 1, the odds for BA advancement increased 120% after adjusting for age and BMI (P=0.033). Conclusion: Insulin resistance could be associated with BA advancement in girls with CPP.
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참고문헌 (25)
참고문헌 신청
[학술지(정기간행물
Biro FM / 2006 / Influence of obesity on timing of puberty / Int J Androl 29 : 272 ~ 277
Bordini B / 2009 / Blunted sleeprelated luteinizing hormone rise in healthy premenarcheal pubertal girls with elevated body mass index / J Clin Endocrinol Metab 94 : 1168 ~ 1
Byun SH / 2003 / The fasting serum glucose, insulin and C-peptide levels in children with obesity / J Korean Soc Pediatr Endocrinol 8 : 73 ~ 80
DeFronzo RA / 1991 / Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease / Diab
Biro FM / 2006 / Influence of obesity on timing of puberty / Int J Androl 29 : 272 ~ 277
Bordini B / 2009 / Blunted sleeprelated luteinizing hormone rise in healthy premenarcheal pubertal girls with elevated body mass index / J Clin Endocrinol Metab 94 : 1168 ~ 1
Byun SH / 2003 / The fasting serum glucose, insulin and C-peptide levels in children with obesity / J Korean Soc Pediatr Endocrinol 8 : 73 ~ 80
DeFronzo RA / 1991 / Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease / Diab
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