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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제14권 제2호
- 발행연도
- 2011.1
- 수록면
- 148 - 154 (7page)
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Purpose: We aimed to study the distribution of rotavirus genotypes (VP7 and VP4) and disease severity of rotavirus gastroenteritis prevalent in our community.
Methods: Stool samples were collected from 156 children who were hospitalized with rotavirus gastroenteritis from December 2007 to June 2008. The disease severity of all patients was scored using the Vesikari scale. After extraction of ds-RNA of the rotavirus, cDNA synthesis using reverse transcription and polymerase chain reaction (RT-PCR) and multiplex PCR was performed. Following this, the final identification of genotypes was performed.
Results: Of the 156 samples, VP7(G) and VP4(P) genotypes were identified in 147 (94.2%) and 140 (89.7%) samples, respectively. G1 (116 of 147 samples; 78.9%) and P[8] (137 of 140 samples; 97.9%) were the most prevalent, respectively. Of the 138 samples identified of combination types of VP7 and VP4, G1P[8] (111 samples; 80.4%) was the most prevalent. Other combination types varied with very low distribution rates. 9.4% of genotypes were not included in the new vaccines. The disease severity score was 11.8±3.3 (mean±2SD). The distribution of disease severity was mild or moderate in 37.8% and severe in 62.2% of patients.
Conclusion: The most prevalent genotype combination of rotavirus was G1P[8] and genotypes not included in the vaccines represented 9.4% in our community. Disease severity distribution of hospitalized children with rotavirus gastroenteritis was higher in the severe than in the mild and moderate categories. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 148∼154)
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참고문헌 (27)
참고문헌 신청
최재형 / 2006 / 신경학적 이상이 동반된 로타바이러스 위장관염 환아에서의 로타바이러스 유전형 / Korean Journal of Pediatrics 49(5):513~518
Gleizes O / 2006 / Nosocomial rotavirus infection in european countries: a review of the epidemiology, severity and economic burden of hospital-acquired rotavirus disease / Pediatr Infect Dis J 25:12~21
Jung Oak Kang / 2006 / G and P Genotyping of Human Rotavirus Isolated in a University Hospital in Korea: Implications for Nosocomial Infections / Journal of Korean Medical Science 21(6):983~988
Aupiais C / 2009 / Severity of acute gastroenteritis in infants infected by g1 or g9 rotaviruses / J Clin Virol 46 : 282 ~ 285
Bishop R / 2009 / Discovery of rotavirus: implications for child health / J Gastroenterol Hepatol 24 (3) : 81 ~ 85
Gleizes O / 2006 / Nosocomial rotavirus infection in european countries: a review of the epidemiology, severity and economic burden of hospital-acquired rotavirus disease / Pediatr Infect Dis J 25:12~21
Jung Oak Kang / 2006 / G and P Genotyping of Human Rotavirus Isolated in a University Hospital in Korea: Implications for Nosocomial Infections / Journal of Korean Medical Science 21(6):983~988
Aupiais C / 2009 / Severity of acute gastroenteritis in infants infected by g1 or g9 rotaviruses / J Clin Virol 46 : 282 ~ 285
Bishop R / 2009 / Discovery of rotavirus: implications for child health / J Gastroenterol Hepatol 24 (3) : 81 ~ 85
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