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대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제14권 제1호
발행연도
2011.1
수록면
59 - 66 (8page)

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Purpose: We previously reported that concurrent reactivation of latent Epstein-Barr virus (EBV) in children with hepatitis A virus (HAV) infection is common and EBV reactivation with HAV infection adversely affects the clinical features of hepatitis. However, the incidence of concurrent reactivation was not accurate because the detection of EBV reactivation was based on serologic methods. Therefore, we studied the effects of polymerase chain reaction (PCR)-proven EBV reactivation, thus a more precise concurrence, on acute HAV infection in children. Methods: PCR were conducted in 34 patients, who had enrolled previous study and diagnosed with acute HAV infection between January 2008 and June 2010. Their medical records were reviewed. Results: Among 34 patients with acute HAV infection, 12 patients (35.3%) had EBV reactivation which was proven using serologic and molecular biologic techniques. There were significant differences in the peak levels of AST and ALT between the reactivated and non-reactivated groups (p=0.001 and p＜0.001, respectively). The duration of full recovery from hepatitis was more prolonged in the reactivated group (p＜0.001). Clinical parameters, such as serum protein (p＜0.001) and albumin concentrations (p＜0.001), atypical lymphocyte count (p=0.001), prothrombin time-international normalized ratio (PT-INR, p＜0.001), and splenomegaly (p＜0.001), showed significant differences. The clinical features in the reactivated sub-group ＞10 years of age revealed more liver dysfunction compared to the non-reactivated sub-group. A comparison with a previous study was performed. Conclusion: PCR-proven reactivation of latent EBV in children with HAV infection is common and EBV reactivation with HAV infection adversely affects the clinical features of hepatitis, especially in older children. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 59∼66)
#Epstein-Barr virus #Acute hepatitis A #Polymerase chain reaction

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참고문헌 (23)

참고문헌 신청
Annels NE / 2006 / Management of Epstein-Barr virus (EBV) reactivation after allogeneic stem cell transplantation by simultaneous analysis of EBV DNA load and EBV-specific T google schola Asano N / 2009 / Age-related Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorders: comparison with EBV-positive classic Hodgkin lymphoma in elderly patien google schola Besnard M / 2000 / Intestinal pseudo- obstruction and acute pandysautonomia associated with Epstein-Barr virus infection / Am J Gastroenterol 95 : 280 ~ 284 google schola Chung JL / 2000 / Clinical usefulness of EBV-specific antibody panel test and PCR genotyping in the diagnosis of Epstein-Barr virus infection / Korean J Clin Pathol 20 : 320 google schola Drebber U / 2006 / The role of Epstein-Barr virus in acute and chronic hepatitis / J Hepatol 44 : 879 ~ 885 google schola

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