지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제15권 제2호
- 발행연도
- 2012.1
- 수록면
- 91 - 99 (9page)
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Purpose: The aims of this study was to compare and evaluate the clinical characteristics, laboratory data, and prognosis for infants under age 1 year with CMV hepatitis and those with viral hepatitis of unknown etiology. Methods: A retrospective study was conducted of infants under age 1 year who were admitted with acute hepatitis. The exclusion criteria consisted of: autoimmune, genetic, metabolic, toxic, HAV, HBV, HCV, toxoplasma, rubella, herpes simplex, and Epstein‐Barr virus. The 30 patients included were divided into two groups based on markers for CMV (IgM anti‐CMV, CMV PCR in urine, CMV culture in urine). Results: The median age of patients (n=15) was 2.8 months. No other organ involvement was detected in any patient. Peak serum total bilirubin levels (n=4) ranged from 2.6 to 6.7 mg/dL. Peak serum ALT levels ranged from 51 to 1,581 IU/L. The duration of ALT elevation ranged from 1.5 weeks to 26 weeks (median 9 weeks). All had recovered in full without ganciclovir; there were no cases of hearing loss. The median age of controls (n=15) was 2.5 months. Peak serum total bilirubin levels (n=4) ranged from 1.6 to 9.1 mg/dL. Peak serum ALT levels ranged from 26 to 1,794 IU/L. No significant differences were observed between both groups regarding the peak serum ALT levels, peak serum total bilirubin levels, duration of hyperbilirubinemia and ALT elevation. Conclusion: Although it was not possible to differentiate congenital infection with perinatal infection in this study, the prognosis of patients with CMV hepatitis without other organ involvement was good without ganciclovir treatment.
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참고문헌 (25)
참고문헌 신청
AAP committee on infectious diseases / 2009 / cytomegalovirus infection, In Red book. 28th ed / American academy of pediatrics : 275 ~ 280
Chomel JJ / 2001 / Role of cytomegalovirus infection in the incidence of viral acute respiratory infections in children attending day-care centers / Eur J Clin Microbiol Infe
Demmler-Harrison GJ / 2009 / Cytomegalovirus, In Textbook of pediatric infectious diseases. 6th ed / Saunders : 2022 ~ 2043
Emerick K / 2010 / Hepatitis in Children due to Non-A?E Viruses. In: Jonas MM. Viral Hepatitis in Children: Unique Features and Opportunities. 1st ed / Humana Press : 111 ~ 127
Enright AM / 2003 / Neurologic sequelae of congenital infection, In Fetal and Neonatal Brain Injury: Mechanisms, Management, and the Risks of Practice. 3rd ed / Cambridge University Pre
Chomel JJ / 2001 / Role of cytomegalovirus infection in the incidence of viral acute respiratory infections in children attending day-care centers / Eur J Clin Microbiol Infe
Demmler-Harrison GJ / 2009 / Cytomegalovirus, In Textbook of pediatric infectious diseases. 6th ed / Saunders : 2022 ~ 2043
Emerick K / 2010 / Hepatitis in Children due to Non-A?E Viruses. In: Jonas MM. Viral Hepatitis in Children: Unique Features and Opportunities. 1st ed / Humana Press : 111 ~ 127
Enright AM / 2003 / Neurologic sequelae of congenital infection, In Fetal and Neonatal Brain Injury: Mechanisms, Management, and the Risks of Practice. 3rd ed / Cambridge University Pre
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