지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제19권 제4호
- 발행연도
- 2014.1
- 수록면
- 208 - 213 (6page)
이용수
초록· 키워드
오류제보하기
Purpose: The gonadotropin-releasing hormone agonist (GnRHa) is widely used to treat patients with precocious puberty. However, its effect on growth is often difficult to predict because of the diverse nature of its causes and presentation.
This study aims to show the impact of GnRHa treatment on insulin-like growth factor-1 (IGF-I) and IGF binding protein-3 (IGFBP-3) secretion, growth, and on other parameters that may help estimate the height velocity.
Methods: Data from 60 girls (mean age, 8.8±0.7 years) treated with GnRHa were analyzed. Their height, bone age (BA), serum IGF-I, and IGFBP-3 concentrations were measured at the start and after a year of GnRHa treatment. To eliminate the confounding effect of chronological age (CA), the standard deviation scores (SDSs) of their height, IGF-I, and IGFBP-3 concentrations according to their CA at the start and after a year of GnRHa treatment were calculated. We looked for possible correlations between these variables and compared the subgroups based on their height velocities and midparental heights.
Results: During their one-year GnRHa therapy, height SDS for CA significantly decreased to 0.81±0.83 (P<0.001), but height SDS for BA increased to –0.28±0.68 (P<0.001). There was no significant change in serum IGF-I SDS, IGFBP-3 SDS, and IGF-I/IGFBP-3 ratio. The advanced BA was the factor most strongly correlated to the height velocity (R=0.265, P=0.041).
Conclusion: These findings suggest that GnRHa treatment may affect the height velocity due to mechanisms other than suppression of the IGF-I and IGFBP-3 secretory axis.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Kanety H / 1996 / Insulinlike growth factor-I and IGF binding protein-3 remain high after GnRH analogue therapy in girls with central precocious puberty / Clin Endocrinol 45:7~12
Sklar CA / 1991 / Suppression of the pituitary-gonadal axis in children with central precocious puberty: effects on growth, growth hormone, insulin-like growth factor-I, and prolactin secretion / J Clin Endocrinol Metab 73:734~738
Belgorosky A / 1994 / Serum IGF-I during treatment of three different types of abnormal puberty, possible role of IGF-I in pubertal maturation / Proceedings of the 76th Annual Meeting of the Endocrine Society
Weise M / 2004 / Determinants of growth during gonadotropin-releasing hormone analog therapy for precocious puberty / J Clin Endocrinol Metab 89:103~107
이승재 / 2012 / Effects of Gonadotropin-Releasing Hormone Agonist Therapy on Body Mass Index and Height in Girls with Central Precocious Puberty / 전남의대학술지 48(1):27~31
Sklar CA / 1991 / Suppression of the pituitary-gonadal axis in children with central precocious puberty: effects on growth, growth hormone, insulin-like growth factor-I, and prolactin secretion / J Clin Endocrinol Metab 73:734~738
Belgorosky A / 1994 / Serum IGF-I during treatment of three different types of abnormal puberty, possible role of IGF-I in pubertal maturation / Proceedings of the 76th Annual Meeting of the Endocrine Society
Weise M / 2004 / Determinants of growth during gonadotropin-releasing hormone analog therapy for precocious puberty / J Clin Endocrinol Metab 89:103~107
이승재 / 2012 / Effects of Gonadotropin-Releasing Hormone Agonist Therapy on Body Mass Index and Height in Girls with Central Precocious Puberty / 전남의대학술지 48(1):27~31
이 논문의 저자 정보
최근 본 자료
댓글(0)
0