지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background: This study evaluated the relationships between endogenous estrogen levels and vascular risk factors in healthy men and women. Methods: Demographics and laboratory data were collected from normotensive subjects (123 men and 154 women) in their thirties, forties and fifties who had normal laboratory profiles and no cardiovascular risk factors. Initially, estradiol, low-density lipoprotein (LDL)-cholesterol, triglyceride, and high-density lipoprotein (HDL)-cholesterol, systolic and diastolic blood pressure (SBP and DBP), NO2/NO3, homocysteine, and body mass index (BMI) were measured. Then, the relationships between estradiol and the evaluated items were analyzed with comparison of means and correlation, and stepwise multiple regression analysis based on genders and age-groups. Results: Estradiol levels decreased with aging in women. Lower LDL and triglyceride, higher HDL levels, and lower SBP and DBP observed in women were correlated with decreasing age as well as increasing estradiol level. On the multivariate analysis, however, estradiol levels were negatively correlated with the changes in SBP, DBP, and triglyceride among the lipid variables. BMI was positively related with the increase of SBP and DBP and the estradiol levels. Al-though higher NO2/NO3 and lower homocysteine levels were observed in women than men, the NO2/NO3 and homocysteine levels had no significant correlation with estradiol changes. Conclusion: The study observed the beneficial relationships between endogenous estrogen, and blood pressures and lipids in healthy women. The estrogen-related benefits observed in this study were lower TG levels, SBP, and DBP in young women than those in older women or in men. (Korean J Stroke 2011;13:20-26)
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참고문헌 (24)
참고문헌 신청
Dimitrova KR / 2002 / Estrogen and homocysteine / Cardiovasc Res 53:577~588
Nurk E / 2004 / Changes in lifestyle and plasma total homocysteine: the Hordaland Homocysteine Study / Am J Clin Nutr 79:812~819
Fakhrzadeh H / 2006 / Total plasma homocysteine, folate, and vitamin B12 status in healthy Iranian adults: the Tehran homocysteine survey (2003-2004)/a cross-sectional population based study / BMC Public Health 6:29
/ 1995 / Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI)
Barrett-Connor E / 1997 / Sex differences in coronary heart disease. 1. Barrett-Connor E. Sex differences in coronary heart disease. Why are women so superior? The 1995 Ancel
Nurk E / 2004 / Changes in lifestyle and plasma total homocysteine: the Hordaland Homocysteine Study / Am J Clin Nutr 79:812~819
Fakhrzadeh H / 2006 / Total plasma homocysteine, folate, and vitamin B12 status in healthy Iranian adults: the Tehran homocysteine survey (2003-2004)/a cross-sectional population based study / BMC Public Health 6:29
/ 1995 / Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI)
Barrett-Connor E / 1997 / Sex differences in coronary heart disease. 1. Barrett-Connor E. Sex differences in coronary heart disease. Why are women so superior? The 1995 Ancel
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