지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Ischemia-reperfusion injury is complicated with multiple injury pathways. If a particular agent is used to restore blood flow and prevent cell death, many damaged neurons may come back to life. However, for stroke victims, there are no effective curative therapeutic approaches available other than thrombolytic treatment. The efficacy of neuroprotective agents are limited by low diffusion, narrow time window, strict dose titration, and lack of confidence at the preclinical level. NXY-059 reflects the fundamental limitation of neuroprotectant. There are recent attempts to overcome these limitations, with use of annexin A2, fingolimod, hydrogen, nitrite, and more. By covering two components, this report reviews what we have recently learned. In addition, it sheds light on some of the newer issues in clinical application. (Korean J Stroke 2011;13:11-15)
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Dominguez C / 2010 / Santamarina E, et al. Oxidative stress after thrombolysis-induced reperfusion in human stroke / Stroke 41 : 653 ~ 660
Duranski MR / 2005 / Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver / J Clin Invest 115 : 1232 ~ 1240
Ehrenreich H / 2009 / Recombinant human erythropoietin in the treatment of acute ischemic stroke / Stroke 40 : e647 ~ e656
Fan X / 2010 / Annexin A2: a tissue plasminogen activator amplifier for thrombolytic stroke therapy / Stroke 41 : S54 ~ S58
Hasegawa Y / 2010 / Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats / Stroke 41 : 368 ~ 374
Duranski MR / 2005 / Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver / J Clin Invest 115 : 1232 ~ 1240
Ehrenreich H / 2009 / Recombinant human erythropoietin in the treatment of acute ischemic stroke / Stroke 40 : e647 ~ e656
Fan X / 2010 / Annexin A2: a tissue plasminogen activator amplifier for thrombolytic stroke therapy / Stroke 41 : S54 ~ S58
Hasegawa Y / 2010 / Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats / Stroke 41 : 368 ~ 374
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