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학술저널
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대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제19권 제2호
발행연도
2014.1
수록면
96 - 99 (4page)

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Gigantism indicates excessive secretion of growth hormones (GH) during childhood when open epiphyseal growth plates allow for excessive linear growth. Case one involved a 14.7-year-old boy presented with extreme tall stature. His random serum GH level was 38.4 ng/mL, and failure of GH suppression was noted during an oral glucose tolerance test (OGTT; nadir serum GH, 22.7 ng/mL). Magnetic resonance imaging (MRI) of the brain revealed a 12-mm-sized pituitary adenoma. Transsphenoidal surgery was performed and a pituitary adenoma displaying positive immunohistochemical staining for GH was reported. Pituitary MRI scan was performed 4 months after surgery and showed recurrence/residual tumor. Medical treatment with a long-acting somatostatin analogue for six months was unsuccessful. As a result, secondary surgery was performed. Three months after reoperation, the GH level was 0.2 ng/mL and insulin-like growth factor 1 was 205 ng/mL. Case two involved a 14.9-year-old boy, who was referred to our department for his tall stature. His basal GH level was 9.3 ng/mL, and failure of GH suppression was reported during OGTT (nadir GH, 9.0 ng/mL). Pituitary MRI showed a 6-mm- sized pituitary adenoma. Surgery was done and histopathological examination demonstrated a pituitary adenoma with positive staining for GH. Three months after surgery, the GH level was 0.2 ng/mL and nadir GH during OGTT was less than 0.1 ng/mL. Pituitary MRI scans showed no residual tumor. We present two cases of gigantism caused by a GH-secreting pituitary adenoma with clinical and microscopic findings.
#Gigantism #Pituitary adenoma #Growth hormone

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참고문헌 (19)

참고문헌 신청
Abe T / 1999 / Growth hormone-secreting pituitary adenomas in childhood and adolescence: features and results of transnasal surgery / Neurosurgery 45 : 1 ~ 10 google schola Artese R / 1998 / Pituitary tumors in adolescent patients / Neurol Res 20 : 415 ~ 417 google schola Ayuk J / 2004 / Efficacy of Sandostatin LAR (long-acting somatostatin analogue) is similar in patients with untreated acromegaly and in those previously treated with surgery google schola Barrande G / 2000 / Hormonal and metabolic effects of radiotherapy in acromegaly: long-term results in 128patients followed in a single center / J Clin Endocrinol Metab 85 : google schola Bevan JS / 2002 / Primary medical therapy for acromegaly:an open, prospective, multicenter study of the effects of subcutaneous and intramuscular slow-release octreotide on google schola

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