지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background and Purpose Vitamin D deficiency is common across all age groups and may contribute to cardiovascular diseases. Serum 25-hydroxyvitamin D deficiency causing ischemic stroke has been documented in recent reports.
Aim To investigate the association of serum 25-hydroxyvitamin D deficiency with ischemic stroke and subtypes.
Methods We recruited 250 consecutive ischemic stroke patients and 250 age and sex matched controls attending the Department of Neurology, at Yashoda hospital, Hyderabad, India, from January 2011 to December 2012. All ischemic stroke patients underwent stroke subtyping. We measured 25-hydroxyvitamin D by chemiluminescence test, serum calcium, phosphorus, alkaline phosphatase, and C-reactive protein (CRP) in cases and controls.
Results Out of 250 stroke patients, 190 (76%) were men and mean age was 58.4±11.1 years (age range-26-89 years). 25-hydroxyvitamin D deficiency was observed in 122 (48.8%) stroke patients and 79 (31.6%) controls (P=0.001). Among stroke patients, serum 25-hydroxyvitamin D deficiency was found in 54.9% (50/91) of patients with large artery atherosclerosis, 54% (20/37) in cardioembolic stroke, 44.4% (20/45) in small artery diseases, 42.8% (15/35) in stroke of other determined etiology and 40.4% (17/42) in stroke of un-determined etiology. Multiple logistic regression analysis showed an independent association of 25-hydroxyvitamin D deficiency with ischemic stroke (odds ratio: 1.6; 95% CI 1.2-2.8). The association was strongest with large artery atherosclerosis (odds ratio: 2.4; 95% CI 1.6-3.5) and cardioembolic stroke (odds ratio: 2.0; 95% CI 1.0-3.2).
Conclusions We found that 25-hydroxyvitamin D deficiency had an independent association with ischemic stroke. The association was established in large artery arthrosclerosis and cardioembolic stroke.
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참고문헌 (25)
참고문헌 신청
[학술지(정기간행물)]
Adams JrHP. / 1993 / Classification of Subtypes of Acute Ischemic stroke Definitions for use in a multicenter clinical trial TOAST. Trial of Org 10172 in Acute Stroke Treatm
Attia A. / 2010 / Therapeutic potential of 25-hydroxy vitamin D in promoting cardiovascular Health / Arab J of Nephrol and Transplant 3 : 37 ~ 46
Biswas M. / 2009 / Etiology and risk factors of ischemic stroke in Indian American patients from a hospital based registry in New Jersey USA / Neurol Asia 14 : 81 ~ 86
Britov AN. / 2003 / New guidelines of Joint National Committee(USA)on prevention, Diagnosis and Management of Hypertension / From JNC VI to JNC VII Kardiologiia 43 : 93 ~ 97
Adams JrHP. / 1993 / Classification of Subtypes of Acute Ischemic stroke Definitions for use in a multicenter clinical trial TOAST. Trial of Org 10172 in Acute Stroke Treatm
Attia A. / 2010 / Therapeutic potential of 25-hydroxy vitamin D in promoting cardiovascular Health / Arab J of Nephrol and Transplant 3 : 37 ~ 46
Biswas M. / 2009 / Etiology and risk factors of ischemic stroke in Indian American patients from a hospital based registry in New Jersey USA / Neurol Asia 14 : 81 ~ 86
Britov AN. / 2003 / New guidelines of Joint National Committee(USA)on prevention, Diagnosis and Management of Hypertension / From JNC VI to JNC VII Kardiologiia 43 : 93 ~ 97
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