지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background and Purpose Intracerebral hemorrhage (ICH) accounts for approximately 10% of stroke cases. Hypertension may play a role in the pathogenesis of ICH that occurs in the basal ganglia, thalamus, pons, and cerebellum, but not in that of lobar ICH. Hypertension contributes to decreased elasticity of arteries, thereby increasing the likelihood of rupture in response to acute elevation in intravascular pressure. This study aimed to evaluate arterial stiffness (using the arterial stiffness index [ASI]) in patients with deep (putaminal and thalamic) ICH in comparison with patients with lobar ICH.
Methods We enrolled 64 patients (mean±SD age: 69.3±10.7 years; 47 men and 17 women) among 73 who referred consecutively to our department for intraparenchymal hemorrhage and underwent brain computed tomography (CT) and cerebral angio-CT. In all the subjects, 24-hour heart rates and blood pressures were monitored. The linear regression slope of diastolic on systolic blood pressure was assumed as a global measure of arterial compliance, and its complement (1 minus the slope), ASI, has been considered as a measure of arterial stiffness.
Results In the patients with deep ICH, ASI was significantly higher than in the patients with lobar ICH (0.64±0.19 vs. 0.53±0.17, P=0.04).
Conclusions Our results suggest that in deep ICH, arterial stiffening represents a possible pathogenetic factor that modifies arterial wall properties and contributes to vascular rupture in response to intravascular pressure acute elevation. Therapeutic strategies that reduce arterial stiffness may potentially lower the incidence of deep hemorrhagic stroke.
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참고문헌 (24)
참고문헌 신청
Adji A. / 2011 / Arterial stiffness, its assessment, prognostic value, and implications for treatment / Am J Hypertens 24 : 5 ~ 17
Dolan E. / 2006 / Ambulatory arterial stiffness index as a predictor of cardiovascular mortality in the Dublin Outcome Study / Hypertension 47 : 365 ~ 370
Flaherty ML. / 2005 / Racial variations in location and risk of intracerebral hemorrhage / Stroke 36 : 934 ~ 937
Hatanaka R. / 2011 / Association of arterial stiffness with silent cerebrovascular lesions : the Ohasama study / Cerebrovasc Dis 31 : 329 ~ 337
Keong LH. / 2011 / The role of a high augmentation index in spontaneous intracerebral hemorrhage to prognosticate mortality / Acta Neurochir Suppl 111 : 375 ~ 379
Dolan E. / 2006 / Ambulatory arterial stiffness index as a predictor of cardiovascular mortality in the Dublin Outcome Study / Hypertension 47 : 365 ~ 370
Flaherty ML. / 2005 / Racial variations in location and risk of intracerebral hemorrhage / Stroke 36 : 934 ~ 937
Hatanaka R. / 2011 / Association of arterial stiffness with silent cerebrovascular lesions : the Ohasama study / Cerebrovasc Dis 31 : 329 ~ 337
Keong LH. / 2011 / The role of a high augmentation index in spontaneous intracerebral hemorrhage to prognosticate mortality / Acta Neurochir Suppl 111 : 375 ~ 379
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