지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Background Major stroke clinical trials have failed during the past decades. The failures suggest the presence of heterogeneity among stroke patients. Biomarkers refer to indicators found in the blood, other body fluids or tissues that predicts physiologic or disease states, increased disease risk, or pharmacologic responses to a therapeutic intervention. Stroke biomarkers could be used as a guiding tool for more effective personalized therapy.
Main Contents Three aspects of stroke biomarkers are explored in detail. First, the possible role of biomarkers in patients with stroke is discussed. Second, the limitations of conventional biomarkers (especially protein biomarkers) in the area of stroke research are presented with the reasons. Lastly, various types of biomarkers including traditional and novel genetic,microvesicle, and metabolomics-associated biomarkers are introduced with their advantages and disadvantages. We especially focus on the importance of comprehensive approaches using a variety of stroke biomarkers.
Conclusion Although biomarkers are not recommended in practice guidelines for use in the diagnosis or treatment of stroke, many efforts have been made to overcome the limitations of biomarkers. The studies reviewed herein suggest that comprehensive analysis of different types of stroke biomarkers will improve the understanding of individual pathophysiologies and further promote the development of screening tools for of high-risk patients, and predicting models of stroke outcome and rational stroke therapy tailored to the characteristics of each case.
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참고문헌 (119)
참고문헌 신청
Pikula A / 2012 / Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study / Circulation 125:2100~2107
Yamada Y / 2009 / Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study / Atherosclerosis 207:144~149
Penttila K / 2002 / Myoglobin, creatine kinase MB isoforms and creatine kinase MB mass in early diagnosis of myocardial infarction in patients with acute chest pain / Clin Biochem 35:647~653
Gibler WB / 2003 / Evaluation of chest pain and heart failure in the emergency department: impact of multimarker strategies and b-type natriuretic peptide / Rev Cardiovasc Med 4:47~55
Stein PD / 2004 / D-dimer for the exclusion of acute venous thrombosis and pulmonary embolism: a systematic review / Ann Intern Med 140:589~602
Yamada Y / 2009 / Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study / Atherosclerosis 207:144~149
Penttila K / 2002 / Myoglobin, creatine kinase MB isoforms and creatine kinase MB mass in early diagnosis of myocardial infarction in patients with acute chest pain / Clin Biochem 35:647~653
Gibler WB / 2003 / Evaluation of chest pain and heart failure in the emergency department: impact of multimarker strategies and b-type natriuretic peptide / Rev Cardiovasc Med 4:47~55
Stein PD / 2004 / D-dimer for the exclusion of acute venous thrombosis and pulmonary embolism: a systematic review / Ann Intern Med 140:589~602
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