Online Learning for Classification of Alzheimer Disease based on Cortical Thickness and Hippocampal Shape Analysis

이가영; 김정훈; 김주한; 김기웅; 성준경

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자료유형: 학술저널

저자정보: 이가영 김정훈 김주한 김기웅 성준경

저널정보: 대한의료정보학회 Healthcare Informatics Research Healthcare Informatics Research 제20권 제1호

발행연도: 2014.1

수록면: 61 - 68 (8page)

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연구배경

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Objectives: Mobile healthcare applications are becoming a growing trend. Also, the prevalence of dementia in modern society is showing a steady growing trend. Among degenerative brain diseases that cause dementia, Alzheimer disease (AD) is the most common. The purpose of this study was to identify AD patients using magnetic resonance imaging in the mobile environment. Methods: We propose an incremental classification for mobile healthcare systems. Our classification method is based on incremental learning for AD diagnosis and AD prediction using the cortical thickness data and hippocampus shape. We constructed a classifier based on principal component analysis and linear discriminant analysis. We performed initial learning and mobile subject classification. Initial learning is the group learning part in our server. Our smartphone agent implements the mobile classification and shows various results. Results: With use of cortical thickness data analysis alone, the discrimination accuracy was 87.33% (sensitivity 96.49% and specificity 64.33%). When cortical thickness data and hippocampal shape were analyzed together, the achieved accuracy was 87.52% (sensitivity 96.79% and specificity 63.24%). Conclusions: In this paper, we presented a classification method based on online learning for AD diagnosis by employing both cortical thickness data and hippocampal shape analysis data. Our method was implemented on smartphone devices and discriminated AD patients for normal group.

#Alzheimer Disease #Artificial Intelligence #Classification #Mobile Health Units #Delivery of Health Care

참고문헌 (25)

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[학술지(정기간행물)]

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