Dynamic Model of the Aqueous Humor Circulation with Application to Simulation of the Treatment for Primary Open Angle Glaucoma

Ying Ju; Boliang Wang; Jiezhen Xie; Liwei Huang; Shaohui Huang; Xiaoyang Huang

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자료유형: 학술저널

저자정보: Ying Ju Boliang Wang Jiezhen Xie Liwei Huang Shaohui Huang Xiaoyang Huang

저널정보: 대한의료정보학회 Healthcare Informatics Research Healthcare Informatics Research 제13권 제2호

발행연도: 2007.1

수록면: 139 - 146 (8page)

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Objective: In order to study the mechanism of the aqueous humor circulation and its relationship to the glaucoma macroscopically with engineering methods. Methods: A dynamistic model was presented, which can be used to simulate the situation and the treatment of the primary open angle glaucoma (POAG). The frame of the model was built based on the ophthalmically accepted feedback mechanism between the aqueous humor circulation and the intraocular pressure (IOP). The transfer functions and the parameters were educed from the analysis of physiological theories, the basic elements of hydrodynamics, and the clinical parameters. The relation between the parameters of the system and the episode mechanism of POAG was discussed. A digital method was used to simulate the Challenge test and some medicines' treatment of POAG, and the results were consistent with clinical observations. Results: The results of simulation illuminate that the model can simulate the mechanism of the aqueous humor circulation and the curative mechanism of some medicines under the physiological condition and the pathological condition of the POAG. Conclusion: a few parameters which can hardly be captured with clinical method could be obtained from the model. These parameters can be helpful for the diagnosis and prediction of the curative effect. (Journal of Korean Society of Medical Informatics 13-2, 139-146, 2007)

#Aqueous Humor Circulation #Modeling #Simulation #POAG

참고문헌 (16)

참고문헌 신청

/ / Human Trabecular Meshwork in Primary Culture A Morphological an Autoradiographic Study : 349 ~ 365

/ / Keratocytes and Scleral Fibroblasts in Primary Cell Culture A Comparative Study of Growth Characteristics and Phagocytic Activity by Light and Scanning Electron Microscop

/ / http://www.medsafe.govt.nz/Profs/ Datasheet/a/Apo-Betaxololeyedrops.htm / 1992 / Clinical common data of ophthalmology : 129 ~ 136

/ 1995 / The Glaucomas : 3 ~ 38

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