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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 26 - 30 (5page)
이용수
초록· 키워드
오류제보하기
Background/Aims: Irritable bowel syndrome (IBS) is
a biopsychosocial disorder. 5-Hydroxytryptamine (5-HT)
plays a crucial role in the control of gastrointestinal
motility, sensation, and secretion. This study investigated
changes in platelet-depleted plasma 5-HT and
their correlation with psychopathology in IBS patients
and healthy subjects. Methods: This study involved
21 subjects with IBS and 13 healthy subjects. Fasting
and 1-hr postprandial plasma 5-HT concentrations
were measured. The SCL-90R symptom checklist was
used for the assessment of current psychological
symptoms. Results: Fasting and postprandial plasma
5-HT concentrations were significantly higher in IBS
patients (15.11±13.51 ng/mL and 16.31±14.21 ng/mL,
respectively) than in healthy subjects (5.55±4.14
ng/mL and 6.25±4.82 ng/mL, respectively; p＜0.05).
There were no significant changes between fasting
and 1-hr postprandial 5-HT concentration in IBS subtypes
and healthy subjects. Scores on all SCL-90R
subscales except for the interpersonal-sensitivity subscale
were significantly higher in IBS patients than in
healthy subjects. No correlation was found between
SCL-90R items and platelet-depleted plasma 5-HT
concentration. Conclusions: 5-HT might play a critical
role in IBS, and psychopathological factors are correlated
with IBS.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Bearcroft CP / 1998 / Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study / Gut 42 : 42 ~ 46
Da Prada M / 1972 / Storage of 5-hydroxytryptamine in human blood platelets / Experientia 28 : 1328 ~ 1329
Derogatis LR / 1976 / The SCL-90 and the MMPI: a step in the validation of a new self-report scale / Br J Psychiatry 128 : 280 ~ 289
Drossman DA / 1988 / Psychosocial factors in the irritable bowel syndrome: a multivariate study of patients and nonpatients with irritable bowel syndrome / Gastroenterology 9
Drossman DA / 1993 / U.S. householder survey of functional gastrointestinal disorders: prevalence, sociodemography, and health impact / Dig Dis Sci 38 : 1569 ~ 1580
Da Prada M / 1972 / Storage of 5-hydroxytryptamine in human blood platelets / Experientia 28 : 1328 ~ 1329
Derogatis LR / 1976 / The SCL-90 and the MMPI: a step in the validation of a new self-report scale / Br J Psychiatry 128 : 280 ~ 289
Drossman DA / 1988 / Psychosocial factors in the irritable bowel syndrome: a multivariate study of patients and nonpatients with irritable bowel syndrome / Gastroenterology 9
Drossman DA / 1993 / U.S. householder survey of functional gastrointestinal disorders: prevalence, sociodemography, and health impact / Dig Dis Sci 38 : 1569 ~ 1580
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