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자료유형
학술저널
저자정보
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제8권 제2호
발행연도
2014.1
수록면
170 - 176 (7page)

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Background/Aims: Diversion colitis is the inflammation ofthe excluded segment of the colon in patients undergoingostomy. It has been suggested that a change in colonic floramay lead to colitis; however, direct evidence for this diseaseprogression is lacking. The aim of this study was to evaluatethe relationship between the severity of diversion colitis andthe composition of colonic bacteria. Methsods: We used culturemethods and polymerase chain reaction to analyze thecolonic microflora of patients who underwent rectal cancerresection with or without diversion ileostomy. In the diversiongroup, we also evaluated the severity of colonoscopic andpathologic colitis before reversal. Results: This study enrolled48 patients: 26 in the diversion group and 22 in the controlgroup. Significant differences were observed between thetwo groups in the levels of Staphylococcus (p=0.038), Enterococcus(p<0.001), Klebsiella (p<0.001), Pseudomonas(p=0.015), Lactobacillus (p=0.038), presence of anaerobes(p=0.019), and Bifidobacterium (p<0.001). A significantcorrelation between the severity of colitis and bacterial compositionwas only observed for Bifidobacterium (p=0.005,correlation coefficient=-0.531). Conclusions: The colonicmicroflora differed significantly between the diversion andcontrol groups. Bifidobacterium was negatively correlatedwith the severity of diversion colitis.

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