지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 406 - 410 (5page)
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Background/Aims: Several rescue therapies have been recommended to eradicate Helicobacter pylori infection in patients with a failure of first-line eradication therapy, but they still fail in more than 20% of cases. The aim of this study was to evaluate the efficacy and safety of levofloxacin, metronidazole,and lansoprazole (LML) triple therapy relative to quadruple therapy as a second-line treatment. Methods: In total,113 patients who failed first-line triple therapy for H. pylori infection were randomly assigned to two groups: LML for 7days and tetracycline, bismuth subcitrate, metronidazole and lansoprazole (quadruple) for 7 days. Results: According to intention-to-treat analysis, the infection was eradicated in 38of 56 patients (67.9%) in the LML group and 48 of 57 (84.2%)in the quadruple group (p=0.042). Per-protocol analysis showed successful eradication in 38 of 52 patients (73.1%)from the LML group and 48 of 52 (92.3%) from the quadruple group (p=0.010). There were no significant differences in the adverse effects in either treatment group. Conclusions:LML therapy is less effective than quadruple therapy as a second-line treatment for H. pylori infection. Therefore, quadruple therapy should be considered as the primary secondline strategy for patients experiencing a failure of first-line H.
pylori therapy in Korea.
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참고문헌 (22)
참고문헌 신청
Bilardi C / 2004 / A 10-day levofloxacin-based therapy in patients with resistant Helicobacter pylori infection: a controlled trial / Clin Gastroenterol Hepatol 2 : 997 ~ 10
Di Caro S / 2002 / Levofloxacin based regimens for the eradication of Helicobacter pylori / Eur J Gastroenterol Hepatol 14 : 1309 ~ 1312
Di Caro S / 2009 / Second-line levofloxacin-based triple schemes for Helicobacter pylori eradication / Dig Liver Dis 41 : 480 ~ 485
Fock KM / 2009 / Second Asia-Pacific Consensus Guidelines for Helicobacter pylori infection / J Gastroenterol Hepatol 24 : 1587 ~ 1600
Fuccio L / 2007 / Meta-analysis: duration of first-line proton-pump inhibitor based triple therapy for Helicobacter pylori eradication / Ann Intern Med 147 : 553 ~ 562
Di Caro S / 2002 / Levofloxacin based regimens for the eradication of Helicobacter pylori / Eur J Gastroenterol Hepatol 14 : 1309 ~ 1312
Di Caro S / 2009 / Second-line levofloxacin-based triple schemes for Helicobacter pylori eradication / Dig Liver Dis 41 : 480 ~ 485
Fock KM / 2009 / Second Asia-Pacific Consensus Guidelines for Helicobacter pylori infection / J Gastroenterol Hepatol 24 : 1587 ~ 1600
Fuccio L / 2007 / Meta-analysis: duration of first-line proton-pump inhibitor based triple therapy for Helicobacter pylori eradication / Ann Intern Med 147 : 553 ~ 562
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