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학술저널
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거트앤리버 발행위원회 Gut and Liver Gut and Liver 제5권 제2호
발행연도
2011.1
수록면
187 - 193 (7page)

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Background/Aims: Gastric dysplasia is generally accepted to be the precursor lesion of gastric carcinoma. Approximately 25% to 35% of histological diagnoses based on endoscopic forcep biopsies for gastric dysplastic lesions change following endoscopic resection (ER). The aim of this study was to determine the predictive endoscopic features of highgrade gastric dysplasia (HGD) or early gastric cancer (EGC)following ER for lesions initially diagnosed as low-grade dysplasia (LGD) by a forceps biopsy. Methods: To determine predictive variables for upgraded histology (LGD to HGD or EGC). The lesion size, gross endoscopic appearance, location, and surface nodularity or redness as well as the presence of a depressed portion, Helicobacter pylori infection, and intestinal metaplasia were retrospectively investigated. Results:Among 251 LGDs diagnosed by an initial forceps biopsy, the diagnoses of 100 lesions (39.8%) changed following the ER; 56 of 251 LGDs (22.3%) were diagnosed as HGD, 39(15.5%) as adenocarcinoma, and 5 (2.0%) as chronic gastritis. In a univariate analysis, large lesions (>15 mm), those with a depressed portion, and those with surface nodularity were signifi cantly correlated with a upgraded histology classifi cation following ER. In a multivariate analysis, a large size (>15 mm; odds ratio [OR], 2.8; 95% confi dence interval [CI],1.46 to 5.43) and a depressed portion in the lesion (OR, 2.7;95% CI, 1.44 to 5.03) were predictive factors for upgraded histology following ER. Conclusions: Our study shows that a substantial proportion of diagnoses of low-grade gastric dysplasias based on forceps biopsies were not representative of the entire lesion. We recommend ER for lesions with a depressed portion and for those larger than 15 mm.

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