지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 694 - 703 (10page)
이용수
초록· 키워드
오류제보하기
Background/Aims: Limited data exist comparing the safety and efficacy of direct-acting antivirals (DAAs) in hepatitis C virus (HCV) monoinfected and HCV/human immunodeficiency virus (HIV) coinfected patients in the real-world clinic practice setting. Methods: All HCV monoinfected and HCV/HIV coinfected patients treated with DAAs between January 2014 and October 2017 in community clinic settings were retrospectively analyzed. Pretreatment baseline patient characteristics, treatment efficacy, factors affecting sustained virologic response at 12 weeks (SVR12) after treatment, and adverse reactions were compared between the groups. Results: A total of 327 patients were included in the study, of which 253 were HCV monoinfected, and 74 were HCV/HIV coinfected. There was a statistically significant difference observed in SVR12 when comparing HCV monoinfection and HCV/HIV coinfection (94% and 84%, respectively, p=0.005). However, there were no significant factors identified as a predictor of a reduced response. The most common adverse effect was fatigue (27%). No significant drug interaction was observed between DAA and antiretroviral therapy. None of the patients discontinued the treatment due to adverse events. Conclusions: In a real-world setting, DAA regimens have lower SVR12 in HCV/HIV coinfection than in HCV monoinfection. Further studies involving a higher number of HCV/HIV coinfected patients are needed to identify real predictors of a reduced response.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Balogun MA / 2002 / The prevalence of hepatitis C in England and Wales / J Infect 45:219~226
Mocroft A / 2000 / AIDS across Europe, 1994-98: the EuroSIDA study / Lancet 356:291~296
Kirk GD / 2013 / HIV, age, and the severity of hepatitis C virus-related liver disease: a cohort study / Ann Intern Med 158:658~666
Goedert JJ / 2002 / End-stage liver disease in persons with hemophilia and transfusion-associated infections / Blood 100:1584~1589
Vogel M / 2012 / Liver fibrosis progression after acute hepatitis C virus infection in HIV-positive individuals / Clin Infect Dis 54:556~559
Mocroft A / 2000 / AIDS across Europe, 1994-98: the EuroSIDA study / Lancet 356:291~296
Kirk GD / 2013 / HIV, age, and the severity of hepatitis C virus-related liver disease: a cohort study / Ann Intern Med 158:658~666
Goedert JJ / 2002 / End-stage liver disease in persons with hemophilia and transfusion-associated infections / Blood 100:1584~1589
Vogel M / 2012 / Liver fibrosis progression after acute hepatitis C virus infection in HIV-positive individuals / Clin Infect Dis 54:556~559
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Clinical Characteristics and Treatment Outcomes of Patients with Hepatitis C Virus and Human Immunodeficiency Virus Coinfection: Experience at a Single Center in Korea
Journal of Korean Medical Science
2021 .11
-
Treatment Outcomes of HCV Infection in People Living with HIV: A Case Series from a Single Center in Korea
Infection and Chemotherapy
2024 .09
-
Survey on Hepatitis B virus and Hepatitis C Virus Coinfection in the Human Immunodeficiency Virus-infected Patients
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2022 .09
-
Unmet needs of chronic hepatitis C in the era of direct-acting antiviral therapy
Clinical and Molecular Hepatology
2020 .01
-
Human Immunodeficiency Virus (HIV) and Hepatitis Virus Coinfection among HIV-Infected Korean Patients: The Korea HIV/AIDS Cohort Study
Infection and Chemotherapy
2017 .01
-
Hepatitis C Viral Infection in Children: Updated Review
Pediatric Gastroenterology, Hepatology & Nutrition
2016 .01
-
Efficacy of Direct-Acting Antivirals in Patients with Hepatitis C Virus/Human Immunodeficiency Virus Coinfection: A Gap between Clinical Trial and Real Practice
Gut and Liver
2018 .01
-
Clinical Utility of a New Automated Hepatitis C Virus Core Antigen Assay for Prediction of Treatment Response in Patients with Chronic Hepatitis C
Journal of Korean Medical Science
2016 .01
-
The impact of unrestricted access to direct-acting antiviral among incarcerated hepatitis C virus-infected patients
Clinical and Molecular Hepatology
2021 .01
-
The Korean Hepatitis C Virus Care Cascade in a Tertiary Institution: Current Status and Changes in Testing, Link to Care, and Treatment
Gut and Liver
2022 .11
-
Prevalence of hepatitis B, hepatitis C and human immunodeficiency viral infections in patients with inflammatory bowel disease in north India
Intestinal research
2017 .01
-
Cost-effectiveness of chronic hepatitis C screening and treatment
Clinical and Molecular Hepatology
2022 .04
-
Prevalence, Awareness, and Treatment of Hepatitis C Virus Infection in South Korea: Evidence from the Korea National Health and Nutrition Examination Survey
Gut and Liver
2020 .01
-
The Applications of Hepatitis C Virus (HCV) Replication System in Developing Anti-HCV Reagents
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .06
-
Correspondence on Letter regarding “Toward hepatitis C virus elimination using artificial intelligence”
Clinical and Molecular Hepatology
2024 .04
-
Therapy with Direct-Acting Antiviral Agents for Hepatitis C-Related Liver Cirrhosis
Gut and Liver
2017 .01
-
Hepatocytes infected with hepatitis C virus change immunological features in the liver microenvironment
Clinical and Molecular Hepatology
2023 .01
-
A Survey of the Knowledge of and Testing Rate for Hepatitis C in the General Population in South Korea
Gut and Liver
2020 .01
-
Reactivation of Hepatitis C Virus and Its Clinical Outcomes in Patients Treated with Systemic Chemotherapy or Immunosuppressive Therapy
Gut and Liver
2017 .01
-
Management of hepatitis C viral infection in chronic kidney disease patients on hemodialysis in the era of direct-acting antivirals
Clinical and Molecular Hepatology
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0