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학술저널
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거트앤리버 발행위원회 Gut and Liver Gut and Liver 제8권 제4호
발행연도
2014.1
수록면
408 - 414 (7page)

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Background/Aims: Helicobacter pylori eradication therapyhas been used as a first-line treatment for H. pylori -positivegastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, the management strategy for H. pylori -negativeMALT lymphoma remains controversial. Therefore, the aimof this study was to examine the success rate of each treatmentoption for H. pylori -positive and H. pylori -negativegastric MALT lymphomas. Methods: In total, 57 patientswith gastric MALT lymphoma diagnosed between December2000 and June 2012 were enrolled in the study. The treatmentresponses were compared between H. pylori -positiveand H. pylori -negative gastric MALT lymphomas. Results: Ofthe 57 patients, 43 (75%) had H. pylori infection. Forty-eightpatients received H. pylori eradication as a first-line treatment,and complete remission was achieved in 31 of the 39patients (80%) with H. pylori -positive MALT lymphoma and infive (56%) of the nine patients with H. pylori -negative MALTlymphoma; no significant difference was observed betweenthe groups (p=0.135). The other treatment modalities, includingradiation therapy, chemotherapy, and surgery, wereeffective irrespective of H. pylori infection status, with nosignificant difference in the treatment response between H. pylori -positive and H. pylori -negative MALT lymphomas. Conclusions:H. pylori eradication therapy may be considered asa first-line treatment regardless of H. pylori infection status

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