지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 1 - 9 (9page)
이용수
초록· 키워드
오류제보하기
Gastroesophageal reflux disease (GERD) is the most common cause of noncardiac chest pain (NCCP) and is present in up to 60% of patients with NCCP in Western countries.
In Korea, after a reasonable cardiac evaluation, GERD is reported to underlie 41% of NCCP cases. Typical refl ux symptoms are frequent in Korean patients suffering from NCCP.
Therefore, a careful history of the predominant symptoms,including heartburn and acid regurgitation, is relatively indicative of the GERD diagnosis in Korea. In Korea, in contrast to Western countries, patients aged 40 years and over who have been diagnosed with NCCP but who are without alarming features should undergo endoscopy to exclude gastric cancer or peptic ulcers because of the higher prevalence of peptic ulcer disease and gastric cancers in the region. In a primary care setting, in the absence of any alarming symptoms,a symptomatic response to a trial of a proton pump inhibitor (PPI) is sufficient for the presumptive diagnosis of GERD. In addition, the optimal duration of a PPI test may be at least 2 weeks, as GERD symptoms tend to be less frequent or atypical in Korean patients than in patients from Western countries. In patients diagnosed with GERD-related NCCP, long-term therapy (more than 2 months) with double the standard dose of a PPI is required to alleviate symptoms.
Esophageal dysmotility is relatively uncommon, and pain modulators seem to offer significant improvement of chest pain control in non-GERD-related NCCP. Most traditionally available tricyclics or heterocyclics have many undesirable effects. Therefore, newer drugs with fewer side effects (for example, the serotonin - norepinephrine reuptake inhibitors)may be needed.
목차
등록된 정보가 없습니다.
참고문헌 (62)
참고문헌 신청
Battaglia E / 2005 / Noncardiac chest pain of esophageal origin in patients with and without coronary artery disease / Hepatogastroenterology 52:792~795
Bautista J / 2004 / The effect of an empirical trial of high-dose lansoprazole on symptom response of patients with non-cardiac chest pain: a randomized, doubleblind, placebo-controlled, crossover trial / Aliment Pharmacol Ther 19:1123~1130
Frøbert O / 1995 / Upper endoscopy in patients with angina and normal coronary angiograms / Endoscopy 27:365~370
Dickman R / 2007 / Prevalence of upper gastrointestinal tract findings in patients with noncardiac chest pain versus those with gastroesophageal reflux disease (GERD)-related symptoms: results from a national endoscopic database / Am J Gastroenterol 102:1173~1179
Kapoor N / 2005 / Predictive value of alarm features in a rapid access upper gastrointestinal cancer service / Gut 54:40~45
Bautista J / 2004 / The effect of an empirical trial of high-dose lansoprazole on symptom response of patients with non-cardiac chest pain: a randomized, doubleblind, placebo-controlled, crossover trial / Aliment Pharmacol Ther 19:1123~1130
Frøbert O / 1995 / Upper endoscopy in patients with angina and normal coronary angiograms / Endoscopy 27:365~370
Dickman R / 2007 / Prevalence of upper gastrointestinal tract findings in patients with noncardiac chest pain versus those with gastroesophageal reflux disease (GERD)-related symptoms: results from a national endoscopic database / Am J Gastroenterol 102:1173~1179
Kapoor N / 2005 / Predictive value of alarm features in a rapid access upper gastrointestinal cancer service / Gut 54:40~45
이 논문의 저자 정보
최근 본 자료
댓글(0)
0