지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 29 - 34 (6page)
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Background/Aims: Ulcerative colitis (UC) is sometimes associated with autoimmune pancreatitis (AIP). Infiltration of immunoglobulin G4 (IgG4)-positive plasma cells is sometimes detected in the colonic mucosa of AIP or UC patients. This study aimed to clarify the relation between UC and IgG4.
Methods: Associations with UC were reviewed in 85 AIP patients. IgG4 immunostaining was performed on biopsy specimens from the colonic mucosa of 14 AIP and 32 UC patients.
Results: UC was confirmed in two cases (type 1 AIP, n=1; suspected type 2 AIP, n=1). Abundant infiltration of IgG4-positive plasma cells in the colonic mucosa was detected in the case of suspected type 2 AIP with UC and two cases of type 1 AIP without colitis. Abundant infiltration of IgG4-positive plasma cells was detected in 10 UC cases (IgG4-present, 31%). Although 72% of IgG4-absent UC patients showed mild disease activity, 70% of IgG4-present patients showed moderate to severe disease activity (p<0.05).
Conclusions: UC is sometimes associated with AIP, but it seems that UC is not a manifestation of IgG4-related disease. Infiltration of IgG4-positive plasma cells is sometimes detectable in the colonic mucosa of UC patients and is associated with disease activity.
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참고문헌 (24)
참고문헌 신청
Ball WP / 1950 / Pancreatic lesions associated with chronic ulcerative colitis / Arch Pathol (Chic) 50 : 347 ~ 358
Baron JH / 1964 / Variation between observers in describing mucosal appearances in proctocolitis / Br Med J 1 : 89 ~ 92
Barthet M / 1999 / Chronic pancreatitis and inflammatory bowel disease: true or coincidental association? / Am J Gastroenterol 94 : 2141 ~ 2148
Deheragoda MG / 2007 / The use of immunoglobulin g4 immunostaining in diagnosing pancreatic and extrapancreatic involvement in autoimmune pancreatitis / Clin Gastroenterol H
Heikius B / 1996 / Pancreatic duct abnormalities and pancreatic function in patients with chronic inflammatory bowel disease / Scand J Gastroenterol 31 : 517 ~ 523
Baron JH / 1964 / Variation between observers in describing mucosal appearances in proctocolitis / Br Med J 1 : 89 ~ 92
Barthet M / 1999 / Chronic pancreatitis and inflammatory bowel disease: true or coincidental association? / Am J Gastroenterol 94 : 2141 ~ 2148
Deheragoda MG / 2007 / The use of immunoglobulin g4 immunostaining in diagnosing pancreatic and extrapancreatic involvement in autoimmune pancreatitis / Clin Gastroenterol H
Heikius B / 1996 / Pancreatic duct abnormalities and pancreatic function in patients with chronic inflammatory bowel disease / Scand J Gastroenterol 31 : 517 ~ 523
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