지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 688 - 695 (8page)
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초록· 키워드
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Background/Aims: This study was performed to determine the association between RUNX3 expression and Helicobacter pylori infection in premalignant gastric lesions. Methods: We examined 107 patients with gastric epithelial dysplasia who had undergone endoscopic mucosal resection or submucosal dissection. All tissue samples were evaluated by RUNX3staining and subclassified by immunophenotype. H. pylori infection in dysplastic lesions and the normal surrounding tissue was examined by silver staining, and cagA status was assessed by polymerase chain reaction. Results: The loss of RUNX3 expression was observed in 62 cases (57.9%), and an association with H. pylori infection was found in 54 cases (50.5%). The infection rate with the cagA-positive H. pylori strain was 63.0%. In RUNX3-negative lesions, the rate of H.
pylori infection (p=0.03) and the frequency of category 4 lesions (according to the revised Vienna classification) were high (p=0.02). In addition, the gastric mucin phenotype was predominant. In RUNX3-negative category 4 lesions, the rate of cagA-positive H. pylori infection rate was high but not significantly increased (p=0.08). Conclusions: Infection with H. pylori is associated with inactivation of RUNX3 in early gastric carcinogenesis. This mechanism was prominent in gastric cancer with a gastric mucin phenotype.
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참고문헌 (24)
참고문헌 신청
Brenner O / 2004 / Loss of
Crabtree JE / 1994 / CagA/cytotoxic strains of Helicobacter pylori and interleukin-8 in gastric epithelial cell lines / J Clin Pathol 47 : 945 ~ 950
Hamlet A / 1999 / Duodenal Helicobacter pylori infection differs in cagA genotype between asymptomatic subjects and patients with duodenal ulcers / Gastroenterology 116 : 259
Hatakeyama M / 2004 / Oncogenic mechanisms of the Helicobacter pylori CagA protein / Nat Rev Cancer 4 : 688 ~ 694
Hsu PI / 2009 / Loss of RUNX3 expression correlates with differentiation, nodal metastasis, and poor prognosis of gastric cancer / Ann Surg Oncol 16 : 1686 ~ 1694
Crabtree JE / 1994 / CagA/cytotoxic strains of Helicobacter pylori and interleukin-8 in gastric epithelial cell lines / J Clin Pathol 47 : 945 ~ 950
Hamlet A / 1999 / Duodenal Helicobacter pylori infection differs in cagA genotype between asymptomatic subjects and patients with duodenal ulcers / Gastroenterology 116 : 259
Hatakeyama M / 2004 / Oncogenic mechanisms of the Helicobacter pylori CagA protein / Nat Rev Cancer 4 : 688 ~ 694
Hsu PI / 2009 / Loss of RUNX3 expression correlates with differentiation, nodal metastasis, and poor prognosis of gastric cancer / Ann Surg Oncol 16 : 1686 ~ 1694
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