지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 560 - 568 (9page)
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초록· 키워드
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Background/Aims: Cochinchina momordica seed extract (SK-MS10) has a gastric protective effect. We aimed to assess the effect of SK-MS10 on gastric acid secretion with morphologic changes in the aged rat. Methods: Acid secretions were evaluated in the male F344 rats of four different ages (6-, 31-, 74-week, and 2-year). The 31-week-old rats were divided to three groups and continuously administered chow containing vehicle, SK-MS10 and lansoprazole, respectively.
At the age of 74 weeks and 2 years, basal and stimulated acid was measured and the expression of mRNA and protein of H+-K+-ATPase were determined. The area of connective tissue of lamina propria was measured. Results:Basal and stimulated gastric acid significantly decreased and connective tissue of lamina propria increased with age.
The expression of mRNA and protein of H+-K+-ATPase significantly decreased with age. However, 74-week-old rats in the SK-MS10 group had higher stimulated gastric acid secretion than those in the vehicle and lansoprazole groups. In 2-yearold rats of SK-MS10 group, there was no increase of connective tissue. Conclusions: As SK-MS10 kept the capacity of acid secretion as well as connective tissue area to comparable to young rats, it might valuable to perform further research regarding mechanism of SK-MS10 as an antiaging agent in the stomach.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
/ 2009 / Gastroprotective Action of Cochinchina Momordica Seed Extract Is Mediated by Activation of CGRP and Inhibition of cPLA(2)/5-LOX Pathway / DIGESTIVE DISEASES AND SCI
/ 2010 / Effect of aging on gastric mucosal defense mechanisms: ROS, apoptosis, angiogenesis, and sensory neurons / AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER
Chung SC / 1993 / Age-related differences in gastric acid secretion and response of gastric inhibitory polypeptide after oral glucose in male rats / Chin J Physiol 36 : 219
Du GM / 2007 / Expression of gastric gh
Feldman M / 1996 / Effects of aging and gastritis on gastric acid and pepsin secretion in humans: a prospective study / Gastroenterology 110 : 1043 ~ 1052
/ 2010 / Effect of aging on gastric mucosal defense mechanisms: ROS, apoptosis, angiogenesis, and sensory neurons / AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER
Chung SC / 1993 / Age-related differences in gastric acid secretion and response of gastric inhibitory polypeptide after oral glucose in male rats / Chin J Physiol 36 : 219
Du GM / 2007 / Expression of gastric gh
Feldman M / 1996 / Effects of aging and gastritis on gastric acid and pepsin secretion in humans: a prospective study / Gastroenterology 110 : 1043 ~ 1052
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