지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 460 - 467 (8page)
이용수
초록· 키워드
오류제보하기
Background/Aims: Studies concerning red cell distribution width (RDW) for use in the assessment of infl ammatory bowel disease (IBD) activity are limited. We investigated whether RDW is a marker of active disease in patients with IBD. Methods: In total, 61 patients with ulcerative colitis (UC)and 56 patients with Crohn’s disease (CD) were enrolled in the study group, and 44 age- and-sex-matched healthy volunteers were included as the control group. A CD activity index >150 in patients with CD indicated active disease.
Patients with moderate and severe disease based on the Truelove-Witts criteria were considered to have active UC. In addition to RDW, serum C-reactive protein levels, erythrocyte sedimentation rates, and platelet counts were measured.
Results: Twenty-nine (51.7%) patients with CD and 35 (57.4%)patients with UC had active disease. The RDW was significantly higher in patients with CD and UC than in controls (p<0.001 and p<0.001, respectively). A subgroup analysis indicated that for a RDW cut-off of 14%, the sensitivity for detecting active CD was 79%, and the specicity was 93% (area under curve [AUC], 0.935; p<0.001). RDW was the most sensitive and specifi c marker for active CD. However, it was not valid for UC, as the ESR at a cutoff of 15.5 mm/hr showed a sensitivity of 83% and a specicity of 76% (AUC, 0.817;p<0.001), whereas the RDW at a cutoff of 14% showed 17%sensitivity and 84% specicity for detecting active UC. Conclusions:RDW was elevated in IBD in comparison with healthy controls and increased markedly in active disease. RDW may be a sensitive and specifi c marker for determining active CD,whereas ESR is an important marker of active UC.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Beattie RM / 1995 / Indications for investigation of chronic gastrointestinal symptoms / Arch Dis Child 73 : 354 ~ 355
Brusco G / 2000 / Increased red cell distribution width and coeliac disease / Dig Liver Dis 32 : 128 ~ 130
Cabrera-Abreu JC / 2001 / Performance of blood tests in diagnosis of inflammatory bowel disease in a specialist clinic / Arch Dis Child 89 : 69 ~ 71
Canani RB / 2006 / Combined use of noninvasive tests is useful in the initial diagnostic approach to a child with suspected inflammatory bowel disease / J Pediatr Gastroenter
Chiari MM / 1995 / Influence of acute inflammation on iron and nutritional status indexes in older inpatients / J Am Geriatr Soc 43 : 767 ~ 771
Brusco G / 2000 / Increased red cell distribution width and coeliac disease / Dig Liver Dis 32 : 128 ~ 130
Cabrera-Abreu JC / 2001 / Performance of blood tests in diagnosis of inflammatory bowel disease in a specialist clinic / Arch Dis Child 89 : 69 ~ 71
Canani RB / 2006 / Combined use of noninvasive tests is useful in the initial diagnostic approach to a child with suspected inflammatory bowel disease / J Pediatr Gastroenter
Chiari MM / 1995 / Influence of acute inflammation on iron and nutritional status indexes in older inpatients / J Am Geriatr Soc 43 : 767 ~ 771
이 논문의 저자 정보
최근 본 자료
댓글(0)
0