A Polymorphism in the Microsomal Triglyceride Transfer Protein Can Predict the Response to Antiviral Therapy in Egyptian Patients with Chronic Hepatitis C Virus Genotype 4 Infection

Yasmin Saad; Olfat Shaker; Yasser Nassar; Lama Ahmad; Mohamed Said; Gamal Esmat

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자료유형: 학술저널

저자정보: Yasmin Saad Olfat Shaker Yasser Nassar Lama Ahmad Mohamed Said Gamal Esmat

저널정보: 거트앤리버 발행위원회 Gut and Liver Gut and Liver 제8권 제6호

발행연도: 2014.1

수록면: 655 - 661 (7page)

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Background/Aims: A polymorphism in the microsomal tri-glyceride transfer protein (MTP) is associated with hepatic fi-brosis, and carriers showed higher levels of steatosis, higher levels of hepatitis C virus (HCV) RNA and advanced fibrosis. The aim of this study was to study MTP expression pattern in HCV patients and impact of the MTP polymorphism on the response to antiviral therapy. Methods: One hundred consecutive naive HCV genotype 4 patients were recruited to receive antiviral therapy, and 40 control subjects were also recruited. Demographic, laboratory, and histopathology data were collected. DNA was isolated, and the samples were subjected to polymerase chain reaction analysis and genotyping for MTP by restriction fragment length polymor-phism analysis. Results: Patients and controls were age- and sex-matched (male/female, 56/44, age, 39.2±7.8 years for patients with HCV; male/female, 18/22, age, 38.1±8.1 years for controls). MTP single nucleotide polymorphisms (SNPs) (GG, GT, TT) and alleles (G, T) in the patients versus the controls were 70%, 21%, 9% & 80.5%, 19.5% versus 10%, 87.5%, 2.5% & 53.8%, 46.3%, respectively (p=0.0001). The sustained viral response (SVR) of the patients was 60%. SNPs in MTP genotypes (GG, GT, and TT) and alleles (G and T) in the responders and nonresponders were 71.7%, 25%, 3.3% & 84.2%, 15.8% versus 67.5%, 15%, 17.5% & 75%, 25% (p=0.038 and p=0.109, respectively). A multivariate analysis showed that the GT genotype was an independent predictor of SVR (area under the curve 90% and p=0.0001). Conclusions: MTP could be a new predictor for SVR to anti-viral therapy in patients with HCV genotype 4 infection.

#Microsomal triglyceride transfer protein polymor-phism #Hepatitis C virus #Predictor #Response

참고문헌 (22)

참고문헌 신청

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