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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 321 - 327 (7page)
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Background/Aims: Helicobacter pylori causes numerous extragastric manifestations, including coronary heart disease. The coronary artery calcification (CAC) score, measured using computed tomography (CT) has been used as a screening test for coronary atherosclerosis. This study investigated the association between H. pylori seropositivity and CAC scores in a screening population. Methods: Patients who underwent a health checkup between October 2003 and July 2007 and who did not have a history of ischemic heart disease were enrolled in the study. Subjects were screened with a multi-detector CT scan to determine the CAC score and for anti-H. pylori antibody immunoglobulin G; traditional risks for coronary heart disease were evaluated using a structured questionnaire, anthropometric measurements, and laboratory tests. Results: Of the 2,029 subjects enrolled (1,295 males), 1,214 (59.8%) subjects were H. pylori positive and 815 were H. pylori negative. There were no significant differences in the baseline characteristics of the seropositive and seronegative patients. When the CAC presence or absence scores were considered, multivariate analysis revealed that H. pylori seropositivity was statistically associated with the presence of CAC and that this association was stronger in the mild CAC score category. Conclusions: H. pylori seropositive patients are at a higher risk for coronary atherosclerosis regardless of traditional cardiovascular risk factors. This association is particularly applicable for early coronary atherosclerosis.
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참고문헌 (21)
참고문헌 신청
Budoff MJ / 2006 / Assessment of coronary artery disease by cardiac computed tomography: a scientific statement from the American Heart Association Committee on Cardiovascul
Centers for Disease Control and Prevention (CDC) / 1996 / Cigarette smoking among adults--United States, 1994 / MMWR Morb Mortal Wkly Rep 45 : 588 ~ 590
Dai DF / 2007 / The effects of metabolic syndrome versus infectious burden on inflammation, severity of coronary atherosclerosis, and major adverse cardiovascular events / J
Feldman RA / 1995 / Accuracy of diagnostic methods used for epidemiological studies of Helicobacter pylori / Aliment Pharmacol Ther 9 (Suppl 2) : 21 ~ 31
Ford ES / 2007 / Explaining the decrease in U.S. deaths from coronary disease, 1980-2000 / N Engl J Med 356 : 2388 ~ 2398
Centers for Disease Control and Prevention (CDC) / 1996 / Cigarette smoking among adults--United States, 1994 / MMWR Morb Mortal Wkly Rep 45 : 588 ~ 590
Dai DF / 2007 / The effects of metabolic syndrome versus infectious burden on inflammation, severity of coronary atherosclerosis, and major adverse cardiovascular events / J
Feldman RA / 1995 / Accuracy of diagnostic methods used for epidemiological studies of Helicobacter pylori / Aliment Pharmacol Ther 9 (Suppl 2) : 21 ~ 31
Ford ES / 2007 / Explaining the decrease in U.S. deaths from coronary disease, 1980-2000 / N Engl J Med 356 : 2388 ~ 2398
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