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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 433 - 449 (17page)
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Pancreatic cancer is considered an aggressive malignancy that responds poorly to current treatments and therefore has a dismal survival rate. This disease is usually not diagnosed until a late stage, at which point palliative chemotherapy with the purine analogue gemcitabine and/or a fluoropyrimidine or a platinum agent is the standard approach. There are some new data on the molecular and genetic changes that take place in pancreatic cancer, which may facilitate the accuracy of diagnosis and efficacy of treatments.
However, translational efforts in clinical practice have increased clinicians’ options with a targeted agent, erlotinib,in combination with the standard gemcitabine chemotherapy. Many other novel drugs currently being tested in the field of pharmaco-oncology target various altered biological pathways and molecules. Nevertheless,the lack of clinically significant improvements in treatments is rendering efforts to develop methods of early diagnosis both more urgent and promising. The aim of this review was to summarize the molecular basis of pancreatic carcinogenesis and the latest developments in diagnosis by molecular means, focusing on the results of clinical research into targeted and personalized treatments.
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참고문헌 (23)
참고문헌 신청
Almoguera C / 1988 / Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes / Cell 53 : 549 ~ 553
Bloomston M / 2006 / Epidermal growth factor receptor expression in pancreatic carcinoma using tissue microarray technique / Dig Surg 23 : 74 ~ 79
Dang CX / 2002 / Clinical significance of expression of p21 and p53 proteins and proliferating cell nuclear antigen in pancreatic cancer / Hepatobiliary Pancreat Dis Int 1 :
Dergham ST / 1997 / Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma / Int J Pancreatol 21 : 127 ~ 143
Di Fiore F / 2007 / Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy / Br J Cancer 96 : 1166 ~ 1169
Bloomston M / 2006 / Epidermal growth factor receptor expression in pancreatic carcinoma using tissue microarray technique / Dig Surg 23 : 74 ~ 79
Dang CX / 2002 / Clinical significance of expression of p21 and p53 proteins and proliferating cell nuclear antigen in pancreatic cancer / Hepatobiliary Pancreat Dis Int 1 :
Dergham ST / 1997 / Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma / Int J Pancreatol 21 : 127 ~ 143
Di Fiore F / 2007 / Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy / Br J Cancer 96 : 1166 ~ 1169
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