The Combination of Cyst Fluid Carcinoembryonic Antigen, Cytology and Viscosity Increases the Diagnostic Accuracy of Mucinous Pancreatic Cysts

오세훈; 이종균; 이규택; 이광혁; 우영식; 노동효

추천

검색

자료유형: 학술저널

저자정보: 오세훈 이종균 이규택 이광혁 우영식 노동효

저널정보: 거트앤리버 발행위원회 Gut and Liver Gut and Liver 제11권 제2호

발행연도: 2017.1

수록면: 283 - 289 (7page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background/Aims: The objective of this study was to investigate the value of cyst fluid carcinoembryonic antigen (CEA) in combination with cytology and viscosity for the differential diagnosis of pancreatic cysts. Methods: We retrospectively reviewed our data for patients who underwent endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and cyst fluid analysis. We investigated the sensitivity, specificity and accuracy of the combination of cyst fluid CEA, cytology and viscosity testing. Results: A total of 177 patients underwent EUS-FNA and cyst fluid analysis. Of these, 48 subjects were histologically and clinically confirmed to have pancreatic cysts and were therefore included in the analysis. Receiver operator curve analysis demonstrated that the optimal cutoff value of cyst fluid CEA for differentiating mucinous versus nonmucinous cystic lesions was 48.6 ng/mL. The accuracy of cyst fluid CEA (39/48, 81.3%) was greater than the accuracy of cytology (23/45, 51.1%) or the string sign (33/47, 70.2%). Cyst fluid CEA in combination with cytology and string sign assessment exhibited the highest accuracy (45/48, 93.8%). Conclusions: Cyst fluid CEA was the most useful single test for identifying mucinous pancreatic cysts. The addition of cytology and string sign assessment to cyst fluid CEA increased the overall accuracy for the diagnosis of mucinous pancreatic cysts.

#Pancreatic cyst #Cyst fluid analysis #Cyst fluid carcinoembryonic antigen

참고문헌 (29)

참고문헌 신청

Wiersema MJ / 1997 / Endosonography-guided fine-needle aspiration biopsy: diagnostic accuracy and complication assessment / Gastroenterology 112:1087~1095

Centeno BA / 1997 / Cytologic diagnosis of pancreatic cystic lesions:a prospective study of 28 percutaneous aspirates / Acta Cytol 41:972~980

Leung KK / 2009 / Pancreatic cystic neoplasm:the role of cyst morphology, cyst fluid analysis, and expectant management / Ann Surg Oncol 16:2818~2824

Ahmad NA / 2001 / Can EUS alone differentiate between malignant and benign cystic lesions of the pancreas? / Am J Gastroenterol 96 : 3295 ~ 3300

Attasaranya S / 2007 / Endoscopic ultrasound-guided fine needle aspiration and cyst fluid analysis for pancreatic cysts / JOP 8 : 553 ~ 563

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!