지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 271 - 276 (6page)
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Background/Aims: A link between G protein β3 (GNB3)polymorphism and functional dyspepsia (FD) has been suggested. The aim of this study was to determine the role ofGNB3 polymorphism in the long-term prognosis of FD inKoreans.
Methods: FD patients and normal healthy controlswere recruited from patients who visited our center betweenDecember 2006 and June 2007. All of the subjects completedRome III questionnaires before undergoing upper gastrointestinalendoscopy and colonoscopy. Genomic DNA was extractedfor GNB3 genotyping. After 5 years, the subjects werereevaluated using the same questionnaires.
Results: GNB3825T carrier status was significantly related to FD in Koreans(p=0.04). After 5 years, 61.0% of the initial FD patients and12.2% of the initial normal subjects were diagnosed with FD(odds ratio [OR], 11.7; 95% confidence interval [CI], 4.3 to31.1; p<0.001). Regardless of the GNB3 genotype (p=0.798),female sex was strongly correlated with FD after 5 years (OR,3.3; 95% CI, 1.2 to 9.1; p=0.017).
Conclusions: The T alleleof GNB3 is linked to FD in Koreans but does not predict longtermprognosis. Female sex is related to a higher prevalenceof FD after 5 years.
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참고문헌 (23)
참고문헌 신청
Brook RA / 2010 / Functional dyspepsia impacts absenteeism and direct and indirect costs / Clin Gastroenterol Hepatol 8 : 498 ~ 503
Camilleri CE / 2006 / A study of candidate genotypes associated with dyspepsia in a U.S. community / Am J Gastroenterol 101 : 581 ~ 592
Drossman DA / 2006 / The functional gastrointestinal disorders and the Rome III process / Gastroenterology 130 : 1377 ~ 1390
Ford CE / 1998 / Molecular basis for interactions of G protein beta gamma subunits with effectors / Science 280 : 1271 ~ 1274
Han Gyeol Kim / 2012 / G-Protein Beta3 Subunit C825T Polymorphism in Patients With Overlap Syndrome of Functional Dyspepsia and Irritable Bowel Syndrome / Journal of Neuroga
Camilleri CE / 2006 / A study of candidate genotypes associated with dyspepsia in a U.S. community / Am J Gastroenterol 101 : 581 ~ 592
Drossman DA / 2006 / The functional gastrointestinal disorders and the Rome III process / Gastroenterology 130 : 1377 ~ 1390
Ford CE / 1998 / Molecular basis for interactions of G protein beta gamma subunits with effectors / Science 280 : 1271 ~ 1274
Han Gyeol Kim / 2012 / G-Protein Beta3 Subunit C825T Polymorphism in Patients With Overlap Syndrome of Functional Dyspepsia and Irritable Bowel Syndrome / Journal of Neuroga
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