지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 156 - 163 (8page)
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초록· 키워드
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Background/Aims: This study investigated the protection provided by gabexate mesylate thermo-sensitive in-situ gel (GMTI) against grade III pancreatic trauma in rats. Methods: A grade III pancreatic trauma model with main pancreatic duct dividing was established, and the pancreas anatomical diagram, ascites, and serum biochemical indices, including amylase, lipase, C-reactive protein (CRP), interleukin 6 (IL- 6), and tumor necrosis factor-α (TNF-α), were examined. The pancreas was sliced and stained with hematoxylin eosin and subjected to terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. Results: Ascites, serum amylase, lipase, CRP, IL-6, and TNF-α levels were significantly increased in the pancreas trauma (PT) groups with prolonged trauma time and were significantly decreased after GMTI treatment. The morphological structure of the pancreas was loose, the acinus was significantly damaged, the nuclei were irregular and hyperchromatic, and there was inflammatory cell invasion in the PT group compared to the control. After GMTI treatment, the morphological structure of the pancreas was restored, and the damaged acinus and inflammatory cell invasion were decreased compared to the PT group. Moreover, the cell apoptosis index was significantly increased in the PT group and restored to the same levels as the control group after GMTI treatment. Conclusions: GMTI, a novel formulation and drug delivery method, exhibited specific effective protection against PT with acute pancreatitis therapy and has potential value as a minimally invasive adjuvant therapy for PT with acute pancreatitis.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Boffard KD / 2000 / Pancreatic trauma: injuries to the pancreas and pancreatic duct / Eur J Surg 166 : 4 ~ 12
Chiang PR / 2013 / Thermosensitive hydrogel from oligopeptide-containing amphiphilic block copolymer: effect of peptide functional group on self-assembly and gelation behavi
Dawson AR / 1985 / Rupture of the head of the pancreas by blunt trauma: a case report / S Afr Med J 67 : 560 ~ 562
Gigante A / 2013 / Gabexate mesylate as treatment in the course of ANCA-negative microscopic polyangiitis / Ren Fail 35 : 721 ~ 724
Gupta A / 2004 / Blunt trauma of the pancreas and biliary tract: a multimodality imaging approach to diagnosis / Radiographics 24 : 1381 ~ 1395
Chiang PR / 2013 / Thermosensitive hydrogel from oligopeptide-containing amphiphilic block copolymer: effect of peptide functional group on self-assembly and gelation behavi
Dawson AR / 1985 / Rupture of the head of the pancreas by blunt trauma: a case report / S Afr Med J 67 : 560 ~ 562
Gigante A / 2013 / Gabexate mesylate as treatment in the course of ANCA-negative microscopic polyangiitis / Ren Fail 35 : 721 ~ 724
Gupta A / 2004 / Blunt trauma of the pancreas and biliary tract: a multimodality imaging approach to diagnosis / Radiographics 24 : 1381 ~ 1395
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