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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 13 - 26 (14page)
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초록· 키워드
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Cholangiocarcinoma (CCA) is the second most common primary malignancy. Although it is more common in Asia, its incidence in Europe and North America has significantly increased in recent decades. The prognosis of CCA is dismal.
Surgery is the only potentially curative treatment, but the majority of patients present with advanced stage disease, and recurrence after resection is common. Over the last two decades, our understanding of the molecular biology of this malignancy has increased tremendously, diagnostic techniques have evolved, and novel therapeutic approaches have been established. This review discusses the changing epidemiologic trends and provides an overview of newly identified etiologic risk factors for CCA. Furthermore, the molecular pathogenesis is discussed as well as the influence of etiology and biliary location on the mutational landscape of CCA.
This review provides an overview of the diagnostic evaluation of CCA and its staging systems. Finally, new therapeutic options are critically reviewed, and future therapeutic strategies discussed.
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참고문헌 (24)
참고문헌 신청
Andersen JB / 2012 / Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors / Gastroenterology 142 : 1021 ~
Bertuccio P / 2013 / A comparison of trends in mortality from primary liver cancer and intrahepatic cholangiocarcinoma in Europe / Ann Oncol 24 : 1667 ~ 1674
Burak K / 2004 / Incidence and risk factors for cholangiocarcinoma in primary sclerosing cholangitis / Am J Gastroenterol 99 : 523 ~ 526
Chalasani N / 2000 / Cholangiocarcinoma in patients with primary sclerosing cholangitis:a multicenter case-control study / Hepatology 31 : 7 ~ 11
Chan-On W / 2013 / Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers / Nat Genet 45 : 1474 ~ 1478
Bertuccio P / 2013 / A comparison of trends in mortality from primary liver cancer and intrahepatic cholangiocarcinoma in Europe / Ann Oncol 24 : 1667 ~ 1674
Burak K / 2004 / Incidence and risk factors for cholangiocarcinoma in primary sclerosing cholangitis / Am J Gastroenterol 99 : 523 ~ 526
Chalasani N / 2000 / Cholangiocarcinoma in patients with primary sclerosing cholangitis:a multicenter case-control study / Hepatology 31 : 7 ~ 11
Chan-On W / 2013 / Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers / Nat Genet 45 : 1474 ~ 1478
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