지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 287 - 294 (8page)
이용수
초록· 키워드
오류제보하기
Multiple endocrine neoplasia type 1 (MEN1) is an inherited autosomal dominant disease presenting with pancreatic neuroendocrine tumors (pNETs), parathyroid tumors, or pituitary tumors. Using the PubMed database, we reviewed the literature on information regarding the proper diagnosis and treatment of MEN1-associated pNET. Many cases of MEN1-associated pNET are functioning pNETs. Gastrinomas and insulinomas tend to occur frequently in the duodenum and pancreas, respectively. In addition to diagnostic imaging, the selective arterial secretagogue injection test (SASI test) is useful for localizing functioning pNET. The standard treatment is surgical resection. However, in the case of a functioning pNET, the tumor should first be accurately located using the SASI test before an appropriate surgical method is selected. In cases of a MEN1-associated non-functioning pNET that exceeds 2 cm in diameter, the incidence of distant metastasis is significantly increased, and surgery is recommended. In cases of unresectable pNET, a somatostatin analog has been shown to demonstrate antitumor effects and is considered to be a promising treatment. In addition, molecular-targeted drugs have recently been found to be effective in phase III clinical trials.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Akerstrom G / 2002 / Timing and extent of surgery in symptomatic and asymptomatic neuroendocrine tumors of the pancreas in MEN 1 / Langenbecks Arch Surg 386 : 558 ~ 569
Bassett JH / 1998 / Characterization of mutations in patients with multiple endocrine neoplasia type 1 / Am J Hum Genet 62 : 232 ~ 244
Brandi ML / 2001 / Guidelines for diagnosis and therapy of MEN type 1 and type 2 / J Clin Endocrinol Metab 86 : 5658 ~ 5671
Cavallari I / 2003 / In situ analysis of human menin in normal and neoplastic pancreatic tissues: evidence for differential expression in exocrine and endocrine cells / J Cli
Chandrasekharappa SC / 1997 / Positional cloning of the gene for multiple endocrine neoplasia-type 1 / Science 276 : 404 ~ 407
Bassett JH / 1998 / Characterization of mutations in patients with multiple endocrine neoplasia type 1 / Am J Hum Genet 62 : 232 ~ 244
Brandi ML / 2001 / Guidelines for diagnosis and therapy of MEN type 1 and type 2 / J Clin Endocrinol Metab 86 : 5658 ~ 5671
Cavallari I / 2003 / In situ analysis of human menin in normal and neoplastic pancreatic tissues: evidence for differential expression in exocrine and endocrine cells / J Cli
Chandrasekharappa SC / 1997 / Positional cloning of the gene for multiple endocrine neoplasia-type 1 / Science 276 : 404 ~ 407
이 논문의 저자 정보
최근 본 자료
댓글(0)
0