지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The hair cycle is into 3 phases including anagen, catagen and telogen. Hair loss is the result of premature catagen caused by apoptotic signal. The process of apoptosis is controlled through the activation of many factors, such as heredity, stress, aging and hormone. Selenarctos thibetanus (bear oil) has been used frequently as an indigenous medicine for moisture, freckle, cold, gray hair and dandruff. In this study, we investigate the effect of bear oil on hair growth in a depilated animal model of C57BL/6 mice. The animals were divided into 4 groups including negative control group (70%EtOH), positive control group (5% MXD), and experimental group (2%, 5% bear oil) and they were topically applied with an amount of 100 μL once a day for 2 weeks.
Topical treatment of 5% bear oil for 2 weeks, hair follicles compared to the group to dorsal skin accelerated hair regrowth faster than 2% bear oil group, minoxidil group and 70% EtOH group. Also, hair density was increased The group treated with bear oil markedly increased the depth and size of the hair follicles in compare to the group treated by minoxidil and 70% EtOH. Also, more hair follicles assumed as in anagen were observed.
This result explains that bear oil has effect on prolong of anagen phase, so bear oil might be a potential new therapeutic source for the hair growth promotion.
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참고문헌 (17)
참고문헌 신청
Chase H / 1953 / Changes in the skin in relation to the hair growth cycle / Anatomic Rec 116 (1) : 75 ~ 82
Couchman JR / 1986 / Rat hair follicle dermal papilla have an extra cellular matrix containing basement membrane components / J Invest Dermatol 87 (6) : 762 ~ 767
Hagemann T / 2005 / Positive lymphocyte transformation testin a patient with allergic contact dermatitis of the scalp after short-term use of topical minoxidil solution / Con
Hamilton JB / 1942 / Male hormone stimulation is prerequisite and an incitement in common baldness / Am J Anat 71 (3) : 451 ~ 480
Herman EH / 1996 / Age dependence of the cardiac lesions induced by minoxidilin the rat / Toxicology 110 : 71 ~ 83
Couchman JR / 1986 / Rat hair follicle dermal papilla have an extra cellular matrix containing basement membrane components / J Invest Dermatol 87 (6) : 762 ~ 767
Hagemann T / 2005 / Positive lymphocyte transformation testin a patient with allergic contact dermatitis of the scalp after short-term use of topical minoxidil solution / Con
Hamilton JB / 1942 / Male hormone stimulation is prerequisite and an incitement in common baldness / Am J Anat 71 (3) : 451 ~ 480
Herman EH / 1996 / Age dependence of the cardiac lesions induced by minoxidilin the rat / Toxicology 110 : 71 ~ 83
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