지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
In order to evaluate the lipid improvement and anti-obesity effect of Cudrania tricuspidata Bureau ethanol extract (CTEE) in high fat diet (HFD)-induced obese mice, hematological and biochemical experiments were conducted.
Experimental animals, six-week-old C57BL/6 male mice, were classified into five groups: normal group (N), control group (C), positive control group (PC, 0.5% catechin), experimental group 1 (E1, 2% Cudrania tricuspidata Bureau stem ethanol extract, CTSEE) and experimental group 2 (E2, 2% Cudrania tricuspidata Bureau leaves ethanol extract, CTLEE). The thirty-five mice, seven in each group, were used. After inducing obesity by providing HFD for four weeks, CTSEE and CTLEE mixed with water were provided for five weeks, ad libitum. Water and feed intake for C, PC, E1 and E2 groups were significantly decreased (p<0.05), compared to N group. Daily body weight gain and feed efficiency significantly decreased (p<0.05) in E1 group, compared to C group. In the hematological analysis, PC, E1 and E2 groups showed significant decrease (p<0.05) in white blood cells, neutrophils, lymphocytes and red blood cells, compared to C group.
In the serum biochemical analysis, AST, ALT, ALP, LDL-C, LDH, insulin, glucose, triglycerides, and total cholesterol levels were significantly decreased (p<0.05) and HDL-C levels were significantly increased (p<0.05) in PC, E1 and E2groups, compared to C group. Especially, E1 group showed the greatest improvement in the above overall parameters,showing its favorable effectiveness in lipid improvement and anti-obesity.
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참고문헌 (38)
참고문헌 신청
Meguro T / 2001 / Oxyhemoglobin induces caspase-mediated cell death in cerebral endothelial cells / J Neurochem 77(3):1128~1135
Meydani M / 2010 / Dietary polyphenols and obesity / Nutri 2(7):737~751
Mlinar B / 2007 / Molecular mechanisms of insulin resistance and associated diseases / Clin Chim Acta 375:20~35
Nagao T / 2007 / A green tea extract high in catechins reduces body fat and cardiovascular risks in humans / Obesity 15(6):1473~1483
Padwal RS / 2007 / Drug treatments for obesity: orlistat, sibutramine, and rimonabant / Lancet 369:71~77
Meydani M / 2010 / Dietary polyphenols and obesity / Nutri 2(7):737~751
Mlinar B / 2007 / Molecular mechanisms of insulin resistance and associated diseases / Clin Chim Acta 375:20~35
Nagao T / 2007 / A green tea extract high in catechins reduces body fat and cardiovascular risks in humans / Obesity 15(6):1473~1483
Padwal RS / 2007 / Drug treatments for obesity: orlistat, sibutramine, and rimonabant / Lancet 369:71~77
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