지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
To evaluate the alleviating effect of black tea water extract (BTWE) on skin-barrier damage and inflammation, the aging animal model was produced by 12 weeks-irradiation of UVB to the backs of 6-7 weeks old female SKH-1 hairless mice three times a week, increasing the intensity each week @ 60 mJ/㎠ (1MED): 1MED at week 1; 2MED at week 2; 3MED at week 3; and 4MED at week 4-12. Then, BTWE was applied to the backs of the aging animals twice a day, 5 days a week for 4 weeks, 200 ㎕ each time (BTWE 1%: 0.13g/kg BW/day, 2%: 0.26g/kg BW/day). The skin erythema indices and transepidermal water loss (TEWL) of the two groups: the positive control (UVB + 0.01% retinoic acid) and experimental (UVB + BTWE) groups, were significantly (p<0.05) lower than the control (UVB + saline) group. Moisture capacities of these two groups were significantly (p<0.05) higher than the control group. The epidermis and dermis of the control group were remarkably thickened in comparison with the normal (no treatment) group. Many inflammatory cells were infiltrated in the dermis of the control group. Whereas, a few inflammatory cells were found in the dermis of the positive control and experimental groups. A large number of mast cells were found in dermis and hypodermis of the control group, and the degree of degranulation was remarkable. Whereas, a considerably less number of mast cells were found in the positive control and experimental groups relative to the control group, and the degree of degranulation was slight, which were similar to the normal group. BTWE could have a considerable improving effects on skin aging in hairless mice induced by UVB irradiation via alleviating of skin-barrier damage and inflammation.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Brenneisen P / 2002 / Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events / Ann NY Acad Sci 973 : 31 ~ 43
Dai G / 2007 / Chronic ultraviolet B irradiation causes loss of hyaluronic acid from mouse dermis because of down-regulation of hyaluronic acid synthases / Am J Physiol 171 :
Duell EA / 1996 / Extraction of human epidermis treated with retinol yields retro-retinoid in addition to free retinol and retinyl esters / J Invest Dermatol 107 (2) : 278 ~
Kang S / 2005 / Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-B and activator protein-1 in inflammatory acne l
Kligman LH / 1986 / The nature of photoaging: it’s prevention and repair / Photodermatology 3 (4) : 215 ~ 227
Dai G / 2007 / Chronic ultraviolet B irradiation causes loss of hyaluronic acid from mouse dermis because of down-regulation of hyaluronic acid synthases / Am J Physiol 171 :
Duell EA / 1996 / Extraction of human epidermis treated with retinol yields retro-retinoid in addition to free retinol and retinyl esters / J Invest Dermatol 107 (2) : 278 ~
Kang S / 2005 / Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-B and activator protein-1 in inflammatory acne l
Kligman LH / 1986 / The nature of photoaging: it’s prevention and repair / Photodermatology 3 (4) : 215 ~ 227
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