지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 225 - 230 (6page)
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초록· 키워드
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Kawasaki disease (KD) is an immune-mediated disease which is a leading cause of acquired cardiovascular disease in developed country. Recently, tumor necrosis factor-alpha (TNF-alpha) blocker, infliximab has been considered a promising option for patients with refractory KD. Although chronic use of a TNF-alpha blocker could increase risk of opportunistic infections, a few studies have documented that use of infliximab was safe without serious adverse effects in patients with KD. We observed serious bacterial infection after infliximab treatment in an infant with refractory KD. Our patient was a 5-month-old male infant diagnosed with KD who did not respond to repeated doses of intravenous immunoglobulin. We effectively treated him with a single infusion of infliximab (5 mg/kg), but gram-negative (Acinetobacter lwoffii) septicemia developed after infliximab infusion. Therefore, we report a case of serious septicemia after treatment with infliximab, and suggest considering the risk of severe infection when deciding whether to prescribe infliximab to an infant with refractory KD.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Adriana H / 2014 / Infliximab for intensification of primary therapy for Kawasaki disease: a phase 3 randomised, double-blind, placebo-controlled trial / The Lancet 83 : 1731
Bergogne BE / 1996 / Acinetobacter spp. as nosocomial pathogens: Microbiological, clinical, and epidemiologic features / Clin Microbiol Rev 9 : 148 ~ 165
Bongartz T / 2006 / Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies:systematic review and meta-analysis of rare harmful
Bruns H / 2009 / Anti-TNF immunotherapy reduces CD8+ T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans / J Clin Invest 119 : 1167 ~ 1177
Burns JC / 1998 / Intravenous gamma-globulin treatment and retreatment in Kawasaki disease. US/Canadian Kawasaki Syndrome Study Group / Pediatr Infect Dis J 17 : 1144 ~ 1148
Bergogne BE / 1996 / Acinetobacter spp. as nosocomial pathogens: Microbiological, clinical, and epidemiologic features / Clin Microbiol Rev 9 : 148 ~ 165
Bongartz T / 2006 / Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies:systematic review and meta-analysis of rare harmful
Bruns H / 2009 / Anti-TNF immunotherapy reduces CD8+ T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans / J Clin Invest 119 : 1167 ~ 1177
Burns JC / 1998 / Intravenous gamma-globulin treatment and retreatment in Kawasaki disease. US/Canadian Kawasaki Syndrome Study Group / Pediatr Infect Dis J 17 : 1144 ~ 1148
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