지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 68 - 79 (12page)
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초록· 키워드
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Purpose:This post-marketing surveillance study (NCT00750360) assessed the safety and reactogenicity of an inactivated, trivalent split-virion influenza vaccine licensed for use in the Korea since 2002.
Methods:Eight hundred and eighty three subjects aged ≥6 months received a single dose of the vaccine; an additional dose was administered to those aged <9 years and unprimed with an influenza vaccine. Four hundred and eleven subjects used diary cards to record safety information; this report presents data from these subjects. Incidence of solicited local, general and unsolicited adverse events (4-days and 21-days post-vaccination follow-up periods, respectively) were recorded. Serious adverse events (SAEs) were recorded throughout the study period.
Results:Injection site pain (subjects aged <6 years: 12.6% of subjects, ≥6 years: 34.7%), fever (<6 years: 1.3%) and myalgia (≥6 years: 13.9%) were the most frequently recorded solicited local and general adverse events. Grade 3 solicited adverse events were reported by ≤4.0% subjects. No vaccine-related SAEs were recorded (KFDA criteria).
Conclusion:Considering the vaccine’s well-established immunogenicity and its favourable safety and reactogenicity profile across all age groups and its high coverage rate in Korea, it may be recommended as a candidate to facilitate annual seasonal influenza vaccination for all ages as part of the Korean National Immunization Program.
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참고문헌 (22)
참고문헌 신청
Chun BC / 1999 / Preventive efficacy of influenza vaccination against to influenza-like illness among eldery / Korean J Epidemiol 21 : 205 ~ 219
El Sahly HM / 2008 / Clinical data on FluarixTM: an inactivated split seasonal influenza vaccine / Expert Rev Vaccines 7 : 713 ~ 719
Fiore AE / 2009 / Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009 / MMWR Morb Mor
Glezen WP / 1973 / Epidemiology of acute lower respiratory disease in children / N Engl J Med 288 : 498 ~ 505
Heckler R / 2007 / Cross-Protection against homologous drift variants of influenza A and B after vaccination with split vaccine / Intervirology 50 : 58 ~ 62
El Sahly HM / 2008 / Clinical data on FluarixTM: an inactivated split seasonal influenza vaccine / Expert Rev Vaccines 7 : 713 ~ 719
Fiore AE / 2009 / Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009 / MMWR Morb Mor
Glezen WP / 1973 / Epidemiology of acute lower respiratory disease in children / N Engl J Med 288 : 498 ~ 505
Heckler R / 2007 / Cross-Protection against homologous drift variants of influenza A and B after vaccination with split vaccine / Intervirology 50 : 58 ~ 62
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