지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 40 - 47 (8page)
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Purpose:Norovirus infection, a common cause of community-acquired gastroenteritis, can also lead to severe illness in immunocompromised patients. We investigated clinical manifestations of norovirus infection in pediatric cancer patients.
Methods:Stool specimens were collected from pediatric patients with gastrointestinal symptoms between November 2008 and September 2009 at Samsung Medical Center, Seoul, Korea. Norovirus infection was identified by reverse-transcription polymerase chain reaction (RT-PCR). A retrospective chart review was performed in pediatric cancer patients who were diagnosed with norovirus infection.
Results:Ten patients were diagnosed with norovirus infection by RT-PCR in stool samples. The median age was 0.83 years (range 0.25-5.5 years) and the male to female ratio was 1.5:1 (6 males and 4 females). Underlying diseases were hematologic malignancies (4/10, 40%), neuroblastoma (4/10, 40%), and brain tumors (2/10, 20%). Three patients were infected before hematopoietic cell transplantation (HCT) and four patients after HCT. All patients had diarrhea (10/10, 100%), with a median frequency of diarrhea of 8.5 times/day (range 4-22 times/day). Median virus shedding duration was 72.5 days (range 19-299 days). Four patients with pneumatosis intestinalis were conservatively treated with bowel rest and total parenteral nutrition. One patient with severe diarrhea and bloody stool had concomitant chronic gut graft-versus-host disease (GVHD). Norovirus infection-related mortality was not observed.
Conclusion:Norovirus infection can cause significant clinical manifestations with prolonged viral shedding in immunocompromised patients. Norovirus should be considered in pediatric cancer patients with severe gastrointestinal symptoms.
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참고문헌 (15)
참고문헌 신청
/ 2009 / Pediatrics CoIDotAAo / Red Book
Barker CC / 2005 / GI complications in pediatric patients post-BMT / Bone Marrow Transplant 36 : 51 ~ 58
Boga JA / 2004 / Etiology of sporadic cases of pediatric acute gastroenteritis in asturias, Spain, and genotyping and characterization of norovirus strains involved / J Clin
Kaplan JE / 1982 / The frequency of a Norwalk-like pattern of illness in outbreaks of acute gastroenteritis / Am J Public Health 72 : 1329 ~ 1332
Kim SH / 2005 / Outbreaks of gastroenteritis that occurred during school excursions in Korea were associated with several waterborne strains of norovirus / J Clin Microbiol 4
Barker CC / 2005 / GI complications in pediatric patients post-BMT / Bone Marrow Transplant 36 : 51 ~ 58
Boga JA / 2004 / Etiology of sporadic cases of pediatric acute gastroenteritis in asturias, Spain, and genotyping and characterization of norovirus strains involved / J Clin
Kaplan JE / 1982 / The frequency of a Norwalk-like pattern of illness in outbreaks of acute gastroenteritis / Am J Public Health 72 : 1329 ~ 1332
Kim SH / 2005 / Outbreaks of gastroenteritis that occurred during school excursions in Korea were associated with several waterborne strains of norovirus / J Clin Microbiol 4
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