지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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This study was conducted to evaluate the inhibitory efficacy of water-soluble extracts from green tea (GT), white tea (WT) and black tea (BT) on MMP-2 activity and MMP-1 gene expression in human dermal fibroblasts. In the experiment of MMP-2 activity using a zymography, at the concentrations of 12.5, 25, and 50μg/mL, EGCG decreased it by 15.4, 24.8(p⁄0.05), and 36.1% (p⁄0.01), GT decreased it by 17.1, 27.2 (p⁄0.01), and 38.7% (p⁄0.01), WT decreased it by 1.7,17.6 (p⁄0.05), and 21.2% (p⁄0.05), and BT decreased it by 37.8 (p⁄0.01), 41.5 (p⁄0.001), and 47.5% (p⁄0.001),respectively, compared to the control group. The order of high to low sequence for the inhibitory efficacy on MMP-2activity was BT¤GT¤EGCG¤WT. In the experiment of MMP-1 gene expression using a RT-PCR, at the concentrations of 12.5, 25, and 50 μg/mL, EGCG significantly (p⁄0.001) decreased it by 71.1, 80.6, and 86.9%, GT significantly (p⁄0.001) decreased it by 35.4, 77.6, and 84.6%, WT significantly (p⁄0.001) decreased it by 32.7, 33.1, and 58.4%, and BT significantly (p⁄0.001) decreased it by 49.2, 81.4, and 88.2%, respectively, compared to the control group. The order of high to low sequence for the inhibitory efficacy on MMP-1 gene expression was BT¤EGCG¤GT¤ WT. These results showed that water-soluble extracts from GT, WT and BT had a high inhibitory efficacy on the collagen degradation in human dermal fibroblasts. Especially black tea, which is fermented tea, showed the highest efficacy among the teas tested in this experiment. even better efficacy than EGCG.
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참고문헌 (10)
참고문헌 신청
Barthelman M / 1998 / (-)-epigallocatechin-3-gallate inhibition of ultraviolet B-induced AP-1 activity / Carcinigenesis 19 : 2201 ~ 2204
Chun JH / 2000 / Decreased extracellular-signal regulated kinase and increased stress-activated MAP kinase activites in aged human skin in vivo / J Invest Dermatol 115 : 177
Collier IE / 1988 / H-ras oncogene- transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen / J
Hong SH / 2005 / Ascochlorin inhibits matrix metalloproteinase- 9 expression by suppressing activator protein-1-mediated gene expression through the ER1/2 signaling pathway /
Kondo SJ / 2000 / The roles of cytokines in photoaging / J Dermatol Sci 23 : S30 ~ S36
Chun JH / 2000 / Decreased extracellular-signal regulated kinase and increased stress-activated MAP kinase activites in aged human skin in vivo / J Invest Dermatol 115 : 177
Collier IE / 1988 / H-ras oncogene- transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen / J
Hong SH / 2005 / Ascochlorin inhibits matrix metalloproteinase- 9 expression by suppressing activator protein-1-mediated gene expression through the ER1/2 signaling pathway /
Kondo SJ / 2000 / The roles of cytokines in photoaging / J Dermatol Sci 23 : S30 ~ S36
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