지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The cell viability by XTT assay, DPPH-radical scavenging activity, superoxide dismutase (SOD)-like activity and lipid peroxidation were measured to evaluate the cell injury of chromium trioxide (CrO_3) and the antioxidative effect of lavender (Lavendula angustifolia L.) oil on the cell injury induced by CrO_3 in cultured C6 glioma cells. C6 glioma cells were then treated with the media containing 30~50 μM of CrO_3 for 48 hours. The results of this study showed that CrO_3 remarkably decreased cell viability in dose-dependent manner and the XTT_50 value was appeared at 40.5 μM of CrO_3. In the effect of antioxidant, SOD on CrO_3-mediated cytotoxicity significantly increased the cell viability which was decreased by CrO_3. Meanwhile, in the protective effect of lavender oil on the cytotoxicity induced by CrO_3, it remarkably increased the cell viability damaged by CrO_3-mediated cell injury and also showed the DPPH-radical scavenging activity, SOD-like activity and the inhibitory activity of lipid peroxidation. From these results, it is revealed that the cell injury by CrO_3 was involved in oxidative stress and lavender oil was effective in the protection of CrO_3-mediated cell injury by antioxidative effect.
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참고문헌 (25)
참고문헌 신청
Anderson C / 2000 / Evaluation of massage with essential oils on childhood atopic eczema / Phytother Res 14 (6) : 452 ~ 456
Atsumi T / 2007 / Smelling lavender and rosemary increases free radical scavenging activity and decreases cortisol level in saliva / Psych Res 150 (1) : 89 ~ 96
Bagchi D / 2001 / Chromium (VI)-induced oxidative stress, apoptotic cell death and modulation of p53 tumor suppressor gene / Mol Cell Biochem 222 (1) : 149 ~ 158
Bianchi V / 1980 / Mechanism of chromium toxicity in mammalian cell cultures / Toxicol 17 : 219 ~ 224
Blois MS / 1958 / Antioxidant determination by the use of a stable free radical / Nature 26 : 1199 ~ 1200
Atsumi T / 2007 / Smelling lavender and rosemary increases free radical scavenging activity and decreases cortisol level in saliva / Psych Res 150 (1) : 89 ~ 96
Bagchi D / 2001 / Chromium (VI)-induced oxidative stress, apoptotic cell death and modulation of p53 tumor suppressor gene / Mol Cell Biochem 222 (1) : 149 ~ 158
Bianchi V / 1980 / Mechanism of chromium toxicity in mammalian cell cultures / Toxicol 17 : 219 ~ 224
Blois MS / 1958 / Antioxidant determination by the use of a stable free radical / Nature 26 : 1199 ~ 1200
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