지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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To investigate the alleviative effects of Cnidium officinale water extract (COWE) on inflammation and skin barrier damage, both the irradiation of UVB and the application of squalene monohydroperoxide (Sq-OOH) to the backs of hairless mice were performed for 4 weeks. And at the same time experimental materials were applied topically. The skin erythema indices for the positive control (PC, 0.01% retinoic acid) and experimental (E, COWE) groups were lower than that of the control (C) group. Whereas both the lipid and water capacities for the PC and E groups were higher than those of the C group. Epidermis and dermis of the C group were remarkably thickened in comparison with the PC and E groups.
Relatively much less number of inflammatory cells, including lymphocytes and neutrophils were found in dermis of the PC and E groups compared with the C group. Lipid lamellae of the C group were broken severely, showing an irregular arrangement and lipid content was much reduced. Whereas those of the PC and E groups were almost intact with a regular arrangement, that were similar to that of the N group. Taken the results all together, it was confirmed that COWE could be effective natural herbal material for the alleviation of inflammation and skin barrier damage in hairless mice skin that were induced by UVB irradiation and Sq-OOH application.
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참고문헌 (22)
참고문헌 신청
Blanken R / 1989 / Effect of mineral oil and linoleic-acid-containing emulsions on the skin vapour loss of sodium-lauryl-sulphate-induced irritant skin reactions / Contact De
Brenneisen P / 1997 / Hydrogen peroxide increases the steady mRNA levels of collagenase/MMP-1 in human dermal fibroblasts / Free Rad Biol Med 22 (3) : 515 ~ 524
Chang YB / 2000 / HPLC analysis of retinol in the biological fluids and cutaneous absorption after its transdermal administration / J Phamacy Sci 30 (4) : 283 ~ 288
Chiba K / 1999 / Skin roughness and wrinkle formation induced by repeated application of squalenemonohydroperoxide to the hairless mouse / Exp Dermatol 8 (6) : 471 ~ 479
Chiba K / 2003 / Characteristics of skin wrinkling and dermal changes induced by repeated application of squalene monohydroperoxide to hairless mouse skin / Skin Pharmacol Ap
Brenneisen P / 1997 / Hydrogen peroxide increases the steady mRNA levels of collagenase/MMP-1 in human dermal fibroblasts / Free Rad Biol Med 22 (3) : 515 ~ 524
Chang YB / 2000 / HPLC analysis of retinol in the biological fluids and cutaneous absorption after its transdermal administration / J Phamacy Sci 30 (4) : 283 ~ 288
Chiba K / 1999 / Skin roughness and wrinkle formation induced by repeated application of squalenemonohydroperoxide to the hairless mouse / Exp Dermatol 8 (6) : 471 ~ 479
Chiba K / 2003 / Characteristics of skin wrinkling and dermal changes induced by repeated application of squalene monohydroperoxide to hairless mouse skin / Skin Pharmacol Ap
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